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Experiment + Assay

Phenotypes

Human Diseases

Fig. 2 E

Steimle JD et al. (2018)

Xtr Wt + tbx5 CRISPR

NF35/36 (in situ hybridization)

Expression Phenotype
absent nkx2-1 expression in foregut endoderm absent nkx2-1 expression in lung bud

Fig. 2 F

Steimle JD et al. (2018)

Xtr Wt + tbx5 MO

NF35/36 (in situ hybridization)

Expression Phenotype
absent nkx2-1 expression in foregut endoderm absent nkx2-1 expression in lung bud decreased amount nkx2-1 expression in forebrain decreased amount nkx2-1 expression in thyroid primordium