Larger Image Figure 6. Semaphorin expression in the mesoderm and notochord at tadpole stages. In situ hybridization of the whole embryo (left), dashed line indicates the plane of the transverse section (right). A: Sema3A is expressed in the somites and the splanchnic mesoderm. B: Sema4B expression in the mesoderm is replaced by pronephros, cement gland, otic placode, proctodeum, spinal cord, and gut expression. C: Sema6B is expressed in the somites and otic placode at late neurula stages. D: At tadpole stages, the somite expression is limited to the dorsal and lateral margins of the somites (white arrow). E: Sema3F expression is detected in the notochord, but also in the spinal cord, the hypochord, the posterior endoderm, and the branchial arches. F: Sema4C notochord expression is replaced by expression in the posterior cardinal vein, the heart, and the branchial arches. G: Sema4D expression is detected in the notochord. H: Sema5B expression in the notochord is replaced by spinal cord, pronephros, brain, and eye expression. ba, branchial arches; cg, cement gland; en, endoderm; g, gut; h, heart; hc, hypochord; no, notochord; op, otic placode; p, pronephros; pcv, posterior cardinal vein; pd, proctodeum; s, somites; sc, spinal cord; sm, splanchnic mesoderm. Image published in: Koestner U et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, John Wiley & Sons.
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