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FIGURE 6. The genes involved in tumorigenesis show tissue-specific expression in Xenopus embryos. A, whole mount in situ hybridization (WMISH) detection of expression of genes coding for chromatin modification enzymes. B, WMISH detection of expression of EMT marker genes. Expression of xk81a1 and sox2 is shown as controls. Mid- to late neurula and tailbud embryos were used. Typical expression domains are labeled but the same expression domain in different panels may not be labeled repeatedly. Each embryo is oriented with the anterior to the left. Dorsal view is shown for neurula embryos, and lateral view is shown for tailbud, with dorsal side to the top of each panel. A, anterior; ba, branchial arch; df, dorsal fin; ep, epidermis; ev, ear vesicle; ey, eye; fb, forebrain; hb, hindbrain; he, heart; mb, midbrain; nc, neural crest; np, neural plate; nt, neural tube; P, posterior; pcv, posterior cardinal vein; pl, plexus; pn, pronephros; sc, spinal cord; tb, tailbud.

Image published in: Zhang Z et al. (2017)

Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneSynonymsSpeciesStage(s)Tissue
dnmt1.LDNA MeTase, xDnmt1X. laevisSometime during NF stage 15 to NF stage 20neural plate
neuroectoderm
neural tube
dnmt1.LDNA MeTase, xDnmt1X. laevisSometime during NF stage 26 to NF stage 32intermediate mesoderm
head region
eye
tail bud
vim.Lvim-a, vim-b, vimentinX. laevisSometime during NF stage 15 to NF stage 20neural plate
neural tube
neuroectoderm
vim.Lvim-a, vim-b, vimentinX. laevisSometime during NF stage 26 to NF stage 32head region
branchial arch
vascular plexus
posterior cardinal vein
brain
central nervous system
spinal cord
hdac3.SHDAC, HDm, Rpd3, XRpd3X. laevisSometime during NF stage 15 to NF stage 20neural plate
epidermis
neural tube
neuroectoderm
ectoderm
hdac3.SHDAC, HDm, Rpd3, XRpd3X. laevisSometime during NF stage 26 to NF stage 32branchial arch
head region
spinal cord
otic vesicle
brain
eye
pharyngeal region
central nervous system
intermediate mesoderm
hdac1.Lgon-10, hdac1-a, hdac1-b, rpd3, rpd3l1X. laevisSometime during NF stage 15 to NF stage 20neural plate
neural crest
neural tube
hdac1.Lgon-10, hdac1-a, hdac1-b, rpd3, rpd3l1X. laevisSometime during NF stage 26 to NF stage 32head region
tail bud
spinal cord
intermediate mesoderm
brain
eye
pharyngeal region
central nervous system
hdac2.SMGC81850X. laevisSometime during NF stage 26 to NF stage 32forebrain
midbrain
hindbrain
eye
otic vesicle
central nervous system
ezh2.Lenx-1, enx1, ezh1, ezh2-a, ezh2-b, kmt6, xez, xtezh2X. laevisSometime during NF stage 15 to NF stage 20neural plate
neuroectoderm
neural tube
ezh2.Lenx-1, enx1, ezh1, ezh2-a, ezh2-b, kmt6, xez, xtezh2X. laevisSometime during NF stage 26 to NF stage 32head region
eye
brain
pharyngeal region
kdm1a.Laof2, kdm1, lsd1, xLSD1X. laevisSometime during NF stage 15 to NF stage 20neural plate
neural tube
neuroectoderm
kdm1a.Laof2, kdm1, lsd1, xLSD1X. laevisSometime during NF stage 26 to NF stage 32spinal cord
central nervous system
eye
brain
cdh2.Scadherin-2, cdh2-a, cdh2-b, N-Cad, N-cadherinX. laevisSometime during NF stage 15 to NF stage 20neural plate
neural tube
neuroectoderm
cdh2.Scadherin-2, cdh2-a, cdh2-b, N-Cad, N-cadherinX. laevisSometime during NF stage 26 to NF stage 32forebrain
midbrain
hindbrain
otic vesicle
spinal cord
tail bud
heart
eye
zeb2.Ssip1, smad interaction protein 1, XSip1, XZfhx1b, zfhx1bX. laevisSometime during NF stage 15 to NF stage 20neural plate
neural tube
neuroectoderm
zeb2.Ssip1, smad interaction protein 1, XSip1, XZfhx1b, zfhx1bX. laevisSometime during NF stage 26 to NF stage 32pronephric mesenchyme
midbrain
hindbrain
eye
spinal cord
ctnnb1.LB-catenin, beta catenin, beta-catenin, ctnnb1-a, ctnnb1-b, β-cateninX. laevisSometime during NF stage 15 to NF stage 20neural plate
neuroectoderm
neural tube
ctnnb1.LB-catenin, beta catenin, beta-catenin, ctnnb1-a, ctnnb1-b, β-cateninX. laevisSometime during NF stage 26 to NF stage 32head region
tail bud
intermediate mesoderm
brain
ventral tail fin
spinal cord
otic vesicle
eye
central nervous system
sox2.Lanop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2X. laevisSometime during NF stage 15 to NF stage 20neural plate
neural tube
neuroectoderm
sox2.Lanop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2X. laevisSometime during NF stage 26 to NF stage 32forebrain
midbrain
hindbrain
eye
otic vesicle
brain
snai1.SLOC108702592, sna, snail, snail1, xSna, XsnailX. laevisSometime during NF stage 15 to NF stage 20neural crest
snai1.SLOC108702592, sna, snail, snail1, xSna, XsnailX. laevisSometime during NF stage 26 to NF stage 32branchial arch
brain
pharyngeal region
cdh1.Sarc-1, cd324, cdhe, e-cadherin, ecad, lcam, uvo, uvomorulin, XTCAD-1X. laevisSometime during NF stage 15 to NF stage 20epidermis
non-neural ectoderm
cdh1.Sarc-1, cd324, cdhe, e-cadherin, ecad, lcam, uvo, uvomorulin, XTCAD-1X. laevisSometime during NF stage 26 to NF stage 32dorsal fin
ventral tail fin
epidermis
krt12.4.Lck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1X. laevisSometime during NF stage 15 to NF stage 20epidermis
non-neural ectoderm
krt12.4.Lck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1X. laevisSometime during NF stage 26 to NF stage 32epidermis
dorsal fin
ventral tail fin
eye

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