Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Endocrinol Invest
2000 Oct 01;239:616-22. doi: 10.1007/BF03343785.
Show Gene links
Show Anatomy links
Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class.
Grossmann B
,
Weinbauer G
,
Hirschmann P
,
Vogt PH
.
Abstract
We isolated the complete deleted-in-azoospermia-like-1 (DAZL1) gene of the old world monkey Macaca fascicularis (tentatively designated as MafaDAZL1) and compared its sequence structure to that of the other DAZL1 genes isolated so far. In addition to the homologous RNA recognition motif (RRM domain), we only identified a high conservation of the Mafa-DAZL1 coding region to the mammalian DAZL1 genes (i.e. mouse: Dazl1; and human: DAZL1) and to that of Xenopus (xdazl). Only in the primates, Macaca fascicularis and human, sequences and lengths of the 5' and 3' untranslated DAZL1 gene structures (UTRs) displayed a similar conservation as their coding regions (i.e. 91-94%). Both belong to the primate class of old world monkeys evolutionarily separated 36-55 million years ago (1). The strong conservation of the complete DAZL1 gene structure in both primate species suggests a similar control and maturation pathway of DAZL1 transcripts in the germ line of old world monkeys and also indicates a homologous function of the DAZL1 RNA-binding protein in this primate class.
Burd,
Conserved structures and diversity of functions of RNA-binding proteins.
1994, Pubmed
Burd,
Conserved structures and diversity of functions of RNA-binding proteins.
1994,
Pubmed
Burgoyne,
Fruit(less) flies provide a clue.
1996,
Pubmed
Carani,
cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene.
1997,
Pubmed
Cooke,
A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.
1996,
Pubmed
Eberhart,
Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.
1996,
Pubmed
Gromoll,
The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome.
1999,
Pubmed
Houston,
A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule.
1998,
Pubmed
,
Xenbase
Jackson,
Cytoplasmic regulation of mRNA function: the importance of the 3' untranslated region.
1993,
Pubmed
,
Xenbase
Karashima,
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
2000,
Pubmed
Maegawa,
Maternal mRNA localization of zebrafish DAZ-like gene.
1999,
Pubmed
,
Xenbase
Makalowski,
Evolutionary parameters of the transcribed mammalian genome: an analysis of 2,820 orthologous rodent and human sequences.
1998,
Pubmed
Martin,
Primate origins: plugging the gaps.
1993,
Pubmed
Reijo,
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.
1995,
Pubmed
Reijo,
Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.
1996,
Pubmed
Ruggiu,
The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.
1997,
Pubmed
Ruggiu,
Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells.
2000,
Pubmed
Saxena,
The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.
1996,
Pubmed
Seboun,
Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.
1997,
Pubmed
Shan,
A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.
1997,
Pubmed
Sheets,
Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro.
1990,
Pubmed
Short,
The testis: the witness of the mating system, the site of mutation and the engine of desire.
1997,
Pubmed
Vogt,
Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997.
1998,
Pubmed
Vogt,
Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11.
1997,
Pubmed
Vogt,
Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update.
1998,
Pubmed
Yen,
The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.
1997,
Pubmed
