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Genesis 2001 Jul 01;303:144-8. doi: 10.1002/gene.1051.
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Pitx1 and Pitx2c are required for ectopic cement gland formation in Xenopus laevis.

Schweickert A , Deissler K , Blum M , Steinbeisser H .

The mucus secreting cement gland is the anterior-most ectodermal organ of the Xenopus embryo. The homeobox genes Pltx1 and Pitx2c are expressed in the cement gland primordium. Misexpression of both genes induced ectopic cement gland tissue in whole embryos and transcription of the marker genes Xag1 and Xag2 in animal cap explant cultures. Antisense morpholino oligonucleotides against Pitx1 and Pitx2c inhibited ectopic cement gland formation induced by otx2. Gene knock downs generated by morpholino oligonucleotides were specific and could be rescued by coinjection of Pitx mRNAs. These data demonstrate for the first time the requirement of specific genes for cement gland formation by loss-of-function experiments. genesis 30:144--148, 2001.

PubMed ID: 11477694
Article link: Genesis

Species referenced: Xenopus laevis
Genes referenced: ag1 otx2 pitx1 pitx2 rnf2 tbx2 tbxt

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