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Mech Dev 2001 Sep 01;1071-2:119-31. doi: 10.1016/s0925-4773(01)00458-0.
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The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis.

Paganelli AR , Ocaña OH , Prat MI , Franco PG , López SL , Morelli L , Adamo AM , Riccomagno MM , Matsubara E , Shoji M , Affranchino JL , Castaño EM , Carrasco AE .

We analyzed the influence of presenilins on the genetic cascades that control neuronal differentiation in Xenopus embryos. Resembling sonic hedgehog (shh) overexpression, presenilin mRNA injection reduced the number of N-tubulin+ primary neurons and modulated Gli3 and Zic2 according to their roles in activating and repressing primary neurogenesis, respectively. Presenilin increased shh expression within its normal domain, mainly in the floor plate, whereas an antisense X-presenilin-alpha morpholino oligonucleotide reduced shh expression. Both shh and presenilin promoted cell proliferation and apoptosis, but the effects of shh were widely distributed, while those resulting from presenilin injection coincided with the range of shh signaling. We suggest that presenilin may modulate primary neurogenesis, proliferation, and apoptosis in the neural plate, through the enhancement of shh signaling.

PubMed ID: 11520668
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: dll1 eef1a2 gal.2 gli3 nrp1 pcna psen1 shh slc5a5 tbx2 tubb2b zic2
Morpholinos: psen1 MO1

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