Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-7848
Dev Cell 2002 Jan 01;21:115-24. doi: 10.1016/s1534-5807(01)00107-1.
Show Gene links Show Anatomy links

Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor.

Kramer KL , Yost HJ .


???displayArticle.abstract???
Heparan sulfate proteoglycans expressed on the Xenopus animal cap ectoderm have been implicated in transmitting left-right information to heart and gut primordia. We report here that syndecan-2 functions in the ectoderm to mediate cardiac and visceral situs, upstream of known asymmetrically expressed genes but independently of its ability to mediate fibronectin fibrillogenesis. Left-right development is dependent on a distinct subset of glycosaminoglycan attachment sites on syndecan-2. A novel in vivo approach with enterokinase demonstrates that syndecan-2 functions in left-right patterning during early gastrulation. We describe a cell-nonautonomous role for ectodermal syndecan-2 in transmitting left-right information to migrating mesoderm. The results further suggest that this function may be related to the transduction of Vg1-related signals.

???displayArticle.pubmedLink??? 11782319
???displayArticle.link??? Dev Cell


Species referenced: Xenopus
Genes referenced: fn1 gdf1 lefty nodal nodal1 pitx2 sdc2


???attribute.lit??? ???displayArticles.show???