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Dev Cell 2002 Feb 01;22:171-82. doi: 10.1016/s1534-5807(02)00113-2.
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Intrinsic differences between the superficial and deep layers of the Xenopus ectoderm control primary neuronal differentiation.

Chalmers AD , Welchman D , Papalopulu N .

In Xenopus, primary neurons differentiate early, in the deep layer of the neuroectoderm. In contrast, the neural precursors of the superficial layer continue to proliferate. We report that superficial layer precursors differ from deep layer precursors in that they are refractory to the neuronal-promoting activity of bHLH genes, dominant-negative X-Delta-1, FGF-8, or signals from the organizer. In this system, neuronal differentiation is guided by an early established, intrinsic, cell-autonomous difference in the competence of the precursor cells to differentiate. This difference may be controlled in part by ESR6e, a bHLH gene of the Enhancer-of-split family, which is expressed in the superficial layer of the late blastula and when expressed ectopically suppresses primary neurogenesis in the deep layer.

PubMed ID: 11832243
Article link: Dev Cell

Species referenced: Xenopus
Genes referenced: dll1 hes5.10 ncam1 neurod1 neurog2 notch1 nrp1 sox15 sox3 tubb2b

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