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Members of the Fox gene family exhibit remarkably restricted patterns of expression where they have interesting, required functions during development. We have analyzed the developmental expression patterns of three members of the Fox gene family, FoxJ1.2, FoxJ2, and FoxQ1, which have not been previously described in Xenopus. FoxJ1.2 is expressed in the otic vesicle during late neurula stages and is then also expressed in the presumptive nephrostomes of the pronephros during tailbud stages. FoxJ2 is expressed in the notochord and ventral portion of the neural tube. FoxQ1 is expressed specifically in the pharyngeal pouches as early as neurula stages and remains on in pharyngeal tissue throughout the tailbud stages. At later stages, FoxQ1 is also expressed in the anteriorgut. FoxJ1.2, FoxJ2, and FoxQ1 may prove to be useful tissue-specific markers of these embryonic structures.
Fig. 2. Fox J1.2. Panels A–F show lateral views of embryos with the anterior to the left. Embryos were stained for FoxJ1.2 expression at stages 23 (A,B), 28 (C,D), and 35 (E,F). The second image is a closer view of the stained region. We sectioned and cleared stained stage 28 embryos to visualize staining in the otic vesicle (G) and pronephros (H). The sections correspond to the lines drawn in panel C and are shown with the dorsal side up.
Fig. 3. FoxJ2. Panels A–C show the expression pattern of FoxJ2 at stages 23, 28, and 35, respectively. These panels are lateral views with anterior to the left. We sectioned and cleared a stained stage 28 embryo (D,E). The sections correspond to the lines drawn in panel B and are shown with the dorsal side up.
Fig. 4. FoxQ1. Embryos were stained for FoxQ1 expression at stage 14 (A), 23 (B), 28 (C), 37 (E), and 44 (F,G). Panels A–C,E,F are lateral views with the anterior to the left while G is a ventral view with the anterior to the left. Embryos in panels F,G are cleared. We horizontally sectioned and cleared a stained stage 28 embryo (D). The section is shown with the anterior to the left. We also sectioned and cleared stained stage 44 embryos (H–J). The sections correspond to the lines in panel G and are shown with the dorsal side up and right side of the embryo to the left of the panel. To better illustrate localized staining along the gastrointestinal tract, we have included schematics (K, adapted from (Chalmers and Slack, (2000)). The letter above each schematic indicates the panel to which it corresponds. (Es, esophagus; gb, gallbladder; ht, heart; ia1, first section of intestine leading from stomach; ia2, second section of intestine leading from stomach; ib, external coil of intestine; lu, lung; lv, liver; pa, pancreas; st, stomach).
