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Genesis 2002 Apr 01;324:259-68. doi: 10.1002/gene.10079.
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Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro.

Itäranta P , Lin Y , Peräsaari J , Roël G , Destrée O , Vainio S .

The embryonic kidney is a classic developmental model system for studying inductive tissue interactions that govern organogenesis. We report here that Wnt-6 is expressed in the ureter bud, and that cell lines expressing Wnt-6 induce nephrogenesis in vitro. Wnt-6 cells induce tubules with similar kinetics to spinal cord (SPC) and lead to induced expression of Pax2, Pax8, Sfrp2, and E-cadherin genes, early markers of tubulogenesis. Moreover, Wnt-6 signaling rescues tubulogenesis in mesenchyme separated from Wnt-4 mutant embryos and leads to activation of Wnt-4 transcription. Wnt-6 also induces a secondary axis in early Xenopus embryos. We conclude that Wnt-6 is a candidate for the ureter epithelium-derived signal that leads to activation of kidney tubulogenesis via Wnt-4.

PubMed ID: 11948913
Article link: Genesis

Species referenced: Xenopus
Genes referenced: pax2 pax8 sfrp2 wnt6

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