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Mech Dev 2002 Dec 01;1192:191-200. doi: 10.1016/s0925-4773(02)00361-1.
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Xhex-expressing endodermal tissues are essential for anterior patterning in Xenopus.

Two regions expressing Hex in the early gastrula contribute to organizing the anterior of the vertebrate embryo. In Xenopus, these include the anterior yolky endoderm and the suprablastoporal endoderm (SBE), which is fated to form the epithelial lining of the gut. These tissues may correspond to the anterior visceral endoderm and anterior definitive endoderm of amniotes. Genetic studies in mice have demonstrated the important roles of these tissues in producing anterior identity in the adjacent neural ectoderm. In Xenopus, both the anterior endoderm and the SBE have anterior inducing properties; furthermore, the SBE can organize a full anterior-posterior axis. Inhibition of Xhex function shows that both these Xhex-expressing endodermal tissues are required for anterior development in Xenopus.

PubMed ID: 12464432
Article link: Mech Dev

Species referenced: Xenopus
Genes referenced: actl6a cer1 chrd egr2 en2 foxg1 gsc hhex hoxb9 ncam1 nodal3.1 otx2 sox17b.1 tbxt
Antibodies: Notochord Ab2 Somite Ab1
Morpholinos: hhex MO1

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