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iScience 2024 Apr 19;274:109355. doi: 10.1016/j.isci.2024.109355.
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Quantitative proteome dynamics across embryogenesis in a model chordate.

Frese AN , Mariossi A , Levine MS , Wühr M .

The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate Ciona, covering eight developmental stages and ∼7,000 translated genes, accompanied by a multi-omics analysis of co-evolution with the vertebrate Xenopus. Quantitative proteome comparisons argue against the widely held hourglass model, based solely on transcriptomic profiles, whereby peak conservation is observed during mid-developmental stages. Our analysis reveals maximal divergence at these stages, particularly gastrulation and neurulation. Together, our work provides a valuable resource for evaluating conservation and divergence of multi-omics profiles underlying the diversification of vertebrates.

PubMed ID: 38510129
PMC ID: PMC10951915
Article link: iScience
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: nodal rho sms smyd1
GO keywords: embryo development

Article Images: [+] show captions
References [+] :
Abdul-Wajid, Exploiting the extraordinary genetic polymorphism of ciona for developmental genetics with whole genome sequencing. 2014, Pubmed