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Med Sci (Paris) 2023 Dec 01;3912:967-974. doi: 10.1051/medsci/2023181.
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[The lateral somitic frontier: The source of multipotent somitic cells in Xenopus].

Della Gaspera B , Chanoine C .

The somites are embryonic structures that give rise to the axial musculoskeletal system. In amniotes vertebrates, somites are composed of multipotent somitic cells that quickly compartmentalize into a dorsal dermomyotome and a ventral sclerotome. In the somites, the dermomyotome gives rise to skeletal muscle cells (the myotome) and the dorsal dermis (the dermatome), while the sclerotome gives rise to vertebrae, ribs, and dorsal tendons (the syndetome). The compartmentalization pattern differs in anamniotes, with the establishment of a primitive myotome that begins before somite formation while the LSF (lateral somitic frontier) give rise to both the sclerotome and the dermomyotome in Xenopus. In this synthesis, we describe the contribution of the LSF in establishing somitic lineages in Xenopus and propose a model that traces the evolutionary history of somites back to ancestral precursors associated with striated skeletal muscle.

PubMed ID: 38108728
Article link: Med Sci (Paris)

Species referenced: Xenopus