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XB-ART-60447
Adv Sci (Weinh) 2024 Feb 01;115:e2305202. doi: 10.1002/advs.202305202.
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Optothermal Needle-Free Injection of Vaterite Nanocapsules.

Kislov D , Ofer D , Machnev A , Barhom H , Bobrovs V , Shalin A , Ginzburg P .


Abstract
The propulsion and acceleration of nanoparticles with light have both fundamental and applied significance across many disciplines. Needle-free injection of biomedical nano cargoes into living tissues is among the examples. Here a new physical mechanism of laser-induced particle acceleration is explored, based on abnormal optothermal expansion of mesoporous vaterite cargoes. Vaterite nanoparticles, a metastable form of calcium carbonate, are placed on a substrate, underneath a target phantom, and accelerated toward it with the aid of a short femtosecond laser pulse. Light absorption followed by picosecond-scale thermal expansion is shown to elevate the particle's center of mass thus causing acceleration. It is shown that a 2 µm size vaterite particle, being illuminated with 0.5 W average power 100 fsec IR laser, is capable to overcome van der Waals attraction and acquire 15m sec-1 velocity. The demonstrated optothermal laser-driven needle-free injection into a phantom layer and Xenopus oocyte in vitro promotes the further development of light-responsive nanocapsules, which can be equipped with additional optical and biomedical functions for delivery, monitoring, and controllable biomedical dosage to name a few.

PubMed ID: 38044325
PMC ID: PMC10837343
Article link: Adv Sci (Weinh)
Grant support: [+]

Species referenced: Xenopus laevis


Article Images: [+] show captions