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Int J Mol Sci 2023 Apr 20;248:. doi: 10.3390/ijms24087556.
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Exploring the Structural and Functional Diversity among FGF Signals: A Comparative Study of Human, Mouse, and Xenopus FGF Ligands in Embryonic Development and Cancer Pathogenesis.

Goutam RS , Kumar V , Lee U , Kim J .

Fibroblast growth factors (FGFs) encode a large family of growth factor proteins that activate several intracellular signaling pathways to control diverse physiological functions. The human genome encodes 22 FGFs that share a high sequence and structural homology with those of other vertebrates. FGFs orchestrate diverse biological functions by regulating cellular differentiation, proliferation, and migration. Dysregulated FGF signaling may contribute to several pathological conditions, including cancer. Notably, FGFs exhibit wide functional diversity among different vertebrates spatiotemporally. A comparative study of FGF receptor ligands and their diverse roles in vertebrates ranging from embryonic development to pathological conditions may expand our understanding of FGF. Moreover, targeting diverse FGF signals requires knowledge regarding their structural and functional heterogeneity among vertebrates. This study summarizes the current understanding of human FGF signals and correlates them with those in mouse and Xenopus models, thereby facilitating the identification of therapeutic targets for various human disorders.

PubMed ID: 37108717
PMC ID: PMC10146080
Article link: Int J Mol Sci
Grant support: [+]

Species referenced: Xenopus laevis
GO keywords: embryo development [+]

Disease Ontology terms: cancer

Article Images: [+] show captions
References [+] :
ADHR Consortium, Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. 2000, Pubmed