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Orientations and water dynamics of photoinduced secondary charge-separated states for magnetoreception by cryptochrome.
Hamada M
,
Iwata T
,
Fuki M
,
Kandori H
,
Weber S
,
Kobori Y
.
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In the biological magnetic compass, blue-light photoreceptor protein of cryptochrome is thought to conduct the sensing of the Earth's magnetic field by photoinduced sequential long-range charge-separation (CS) through a cascade of tryptophan residues, WA(H), WB(H) and WC(H). Mechanism of generating the weak-field sensitive radical pair (RP) is poorly understood because geometries, electronic couplings and their modulations by molecular motion have not been investigated in the secondary CS states generated prior to the terminal RP states. In this study, water dynamics control of the electronic coupling is revealed to be a key concept for sensing the direction of weak magnetic field. Geometry and exchange coupling (singlet-triplet energy gap: 2J) of photoinduced secondary CS states composed of flavin adenine dinucleotide radical anion (FAD-•) and radical cation WB(H)+• in the cryptochrome DASH from Xenopus laevis were clarified by time-resolved electron paramagnetic resonance. We found a time-dependent energetic disorder in 2J and was interpreted by a trap CS state capturing one reorientated water molecule at 120 K. Enhanced electron-tunneling by water-libration was revealed for the terminal charge-separation event at elevated temperature. This highlights importance of optimizing the electronic coupling for regulation of the anisotropic RP yield on the possible magnetic compass senses.
Babcock,
Electron-Electron Dipolar Interaction Poses a Challenge to the Radical Pair Mechanism of Magnetoreception.
2020, Pubmed
Babcock,
Electron-Electron Dipolar Interaction Poses a Challenge to the Radical Pair Mechanism of Magnetoreception.
2020,
Pubmed
Balabin,
Exploring biological electron transfer pathway dynamics with the Pathways plugin for VMD.
2012,
Pubmed
Balabin,
Dynamically controlled protein tunneling paths in photosynthetic reaction centers.
2000,
Pubmed
Bellissent-Funel,
Water Determines the Structure and Dynamics of Proteins.
2016,
Pubmed
Beratan,
Protein electron transfer rates set by the bridging secondary and tertiary structure.
1991,
Pubmed
Berntsson,
Photoactivation of Drosophila melanogaster cryptochrome through sequential conformational transitions.
2019,
Pubmed
Biskup,
Direct observation of a photoinduced radical pair in a cryptochrome blue-light photoreceptor.
2009,
Pubmed
Biskup,
Unexpected electron transfer in cryptochrome identified by time-resolved EPR spectroscopy.
2011,
Pubmed
,
Xenbase
Bleifuss,
Tryptophan and tyrosine radicals in ribonucleotide reductase: a comparative high-field EPR study at 94 GHz.
2001,
Pubmed
Brudler,
Identification of a new cryptochrome class. Structure, function, and evolution.
2003,
Pubmed
Burzio,
Reactivity of peptidyl-tyrosine to hydroxylation and cross-linking.
2001,
Pubmed
Chakrabarti,
Experimental evidence for water mediated electron transfer through bis-amino acid donor-bridge-acceptor oligomers.
2009,
Pubmed
Daiyasu,
Identification of cryptochrome DASH from vertebrates.
2004,
Pubmed
,
Xenbase
Di Valentin,
Evidence for water-mediated triplet-triplet energy transfer in the photoprotective site of the peridinin-chlorophyll a-protein.
2014,
Pubmed
Dodson,
A radical sense of direction: signalling and mechanism in cryptochrome magnetoreception.
2013,
Pubmed
Eaton,
Optical spectra and electronic structure of flavine mononucleotide in flavodoxin crystals.
1975,
Pubmed
Edeson,
Studies on the stereochemical assignment of 3-acylidene 2-oxindoles.
2014,
Pubmed
Fogarty,
Water dynamics in protein hydration shells: the molecular origins of the dynamical perturbation.
2014,
Pubmed
Franz,
Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.
2018,
Pubmed
Fuki,
Time Resolved EPR Study on the Photoinduced Long-Range Charge-Separated State in Protein: Electron Tunneling Mediated by Arginine Residue in Human Serum Albumin.
2016,
Pubmed
Hasegawa,
Regulated Electron Tunneling of Photoinduced Primary Charge-Separated State in the Photosystem II Reaction Center.
2017,
Pubmed
Hochstoeger,
The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.
2020,
Pubmed
Hore,
The Radical-Pair Mechanism of Magnetoreception.
2016,
Pubmed
Hoshina,
Exploring the Dynamics of Bound Water in Nylon Polymers with Terahertz Spectroscopy.
2020,
Pubmed
Hosokawa,
Implications of a Water Molecule for Photoactivation of Plant (6-4) Photolyase.
2019,
Pubmed
Kay,
Unambiguous determination of the g-matrix orientation in a neutral flavin radical by pulsed electron-nuclear double resonance at 94 GHz.
2005,
Pubmed
Kay,
Oxidation--reduction midpoint potentials of the flavin, haem and Mo-pterin centres in spinach (Spinacia oleracea L.) nitrate reductase.
1989,
Pubmed
Kobori,
Protein-ligand structure and electronic coupling of photoinduced charge-separated state: 9,10-anthraquinone-1-sulfonate bound to human serum albumin.
2011,
Pubmed
Kobori,
Overcoming Coulombic Traps: Geometry and Electronic Characterizations of Light-Induced Separated Spins at the Bulk Heterojunction Interface.
2015,
Pubmed
Kobori,
Primary charge-recombination in an artificial photosynthetic reaction center.
2005,
Pubmed
Lacombat,
Ultrafast Oxidation of a Tyrosine by Proton-Coupled Electron Transfer Promotes Light Activation of an Animal-like Cryptochrome.
2019,
Pubmed
Liscum,
Blue light signaling through the cryptochromes and phototropins. So that's what the blues is all about.
2003,
Pubmed
Lohmann,
Magnetic orientation by hatchling loggerhead sea turtles (Caretta caretta).
1991,
Pubmed
Lohmann,
Q&A: Animal behaviour: Magnetic-field perception.
2010,
Pubmed
Lüdemann,
Solvent driving force ensures fast formation of a persistent and well-separated radical pair in plant cryptochrome.
2015,
Pubmed
Maeda,
Magnetically sensitive light-induced reactions in cryptochrome are consistent with its proposed role as a magnetoreceptor.
2012,
Pubmed
Maeyama,
Photodetachment spectroscopy of fluorenone radical anions microsolvated with methanol: rationalizing the anomalous solvatochromic behavior due to hydrogen bonding.
2015,
Pubmed
Matsuda,
Electron spin polarization generated by transport of singlet and quintet multiexcitons to spin-correlated triplet pairs during singlet fissions.
2020,
Pubmed
Medvedev,
Protein dynamics control of electron transfer in photosynthetic reaction centers from Rps. sulfoviridis.
2008,
Pubmed
Miura,
Time-Resolved EPR Study of Electron-Hole Dissociations Influenced by Alkyl Side Chains at the Photovoltaic Polyalkylthiophene:PCBM Interface.
2014,
Pubmed
Miura,
Geometries, Electronic Couplings, and Hole Dissociation Dynamics of Photoinduced Electron-Hole Pairs in Polyhexylthiophene-Fullerene Dyads Rigidly Linked by Oligophenylenes.
2016,
Pubmed
Miura,
Effect of molecular diffusion on the spin dynamics of a micellized radical pair in low magnetic fields studied by Monte Carlo simulation.
2015,
Pubmed
Mouritsen,
The magnetic retina: light-dependent and trigeminal magnetoreception in migratory birds.
2012,
Pubmed
Nohr,
Extended Electron-Transfer in Animal Cryptochromes Mediated by a Tetrad of Aromatic Amino Acids.
2016,
Pubmed
Nohr,
Determination of Radical-Radical Distances in Light-Active Proteins and Their Implication for Biological Magnetoreception.
2017,
Pubmed
Okafuji,
G-tensors of the flavin adenine dinucleotide radicals in glucose oxidase: a comparative multifrequency electron paramagnetic resonance and electron-nuclear double resonance study.
2008,
Pubmed
Park,
Crystal structure of DNA photolyase from Escherichia coli.
1995,
Pubmed
Payne,
Reconstitution of Escherichia coli photolyase with flavins and flavin analogues.
1990,
Pubmed
Pogni,
A tryptophan neutral radical in the oxidized state of versatile peroxidase from Pleurotus eryngii: a combined multifrequency EPR and density functional theory study.
2006,
Pubmed
Pokorny,
Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome.
2008,
Pubmed
Ritz,
A model for photoreceptor-based magnetoreception in birds.
2000,
Pubmed
Sang,
N-terminal domain-mediated homodimerization is required for photoreceptor activity of Arabidopsis CRYPTOCHROME 1.
2005,
Pubmed
Savitsky,
Orientation-resolving pulsed electron dipolar high-field EPR spectroscopy on disordered solids: I. Structure of spin-correlated radical pairs in bacterial photosynthetic reaction centers.
2007,
Pubmed
Scott,
Spin-selective charge transport pathways through p-oligophenylene-linked donor-bridge-acceptor molecules.
2009,
Pubmed
Sjulstok,
Quantifying electron transfer reactions in biological systems: what interactions play the major role?
2015,
Pubmed
Sjödin,
Switching the redox mechanism: models for proton-coupled electron transfer from tyrosine and tryptophan.
2005,
Pubmed
Solov'yov,
Separation of photo-induced radical pair in cryptochrome to a functionally critical distance.
2014,
Pubmed
Solov'yov,
Decrypting cryptochrome: revealing the molecular identity of the photoactivation reaction.
2012,
Pubmed
Tamura,
Ultrafast charge separation in organic photovoltaics enhanced by charge delocalization and vibronically hot exciton dissociation.
2013,
Pubmed
Turton,
Terahertz underdamped vibrational motion governs protein-ligand binding in solution.
2014,
Pubmed
Weber,
Origin of light-induced spin-correlated radical pairs in cryptochrome.
2010,
Pubmed
,
Xenbase
Yamada,
Fourier-transform infrared study of the photoactivation process of Xenopus (6-4) photolyase.
2012,
Pubmed
,
Xenbase
Zoltowski,
Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.
2019,
Pubmed