XB-ART-59649Dev Growth Differ 2023 Feb 01;652:109-119. doi: 10.1111/dgd.12836.
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Characteristic tetraspanin expression patterns mark various tissues during early Xenopus development.
The tetraspanins (Tspans) constitute a family of cell surface proteins with four transmembrane domains. Tspans have been found on the plasma membrane and on exosomes of various organelles. Reports on the function of Tspans during the early development of Xenopus have mainly focused on the expression of uroplakins in gametes. Although the roles of extracellular vesicles (EVs) including exosomes have been actively analyzed in cancer research, the contribution of EVs to early development is not well understood. This is because the diffusivity of EVs is not compatible with a very strict developmental process. In this study, we analyzed members of the Tspan family in early development of Xenopus. Expression was prominent in specific organs such as the notochord, eye, cranial neural crest cells (CNCs), trunk neural crest cells, placodes, and somites. We overexpressed several combinations of Tspans in CNCs in vitro and in vivo. Changing the partner changed the distribution of fluorescent-labeled Tspans. Therefore, it is suggested that expression of multiple Tspans in a particular tissue might produce heterogeneity of intercellular communication, which has not yet been recognized.
PubMed ID: 36606534
Article link: Dev Growth Differ
Species referenced: Xenopus laevis
Genes referenced: cd151 cd63 cd81 cd82 cd9 myc rpe tspan14 tspan15 tspan16 tspan17 tspan18 tspan31 tspan33 tspan36 tspan4 tspan9
GO keywords: tetraspanin-enriched microdomain
Disease Ontology terms: cancer
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