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J Theor Biol 2022 Nov 07;551-552:111239. doi: 10.1016/j.jtbi.2022.111239.
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A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis.

Giuraniuc CV , Zain S , Ghafoor S , Hoppler S .

There are two phases of Wnt signalling in early vertebrate embryogenesis: very early, maternal Wnt signalling promotes dorsal development, and slightly later, zygotic Wnt signalling promotes ventral and lateral mesoderm induction. However, recent molecular biology analysis has revealed more complexity among the direct Wnt target genes, with at least five classes. Here in order to test the logic and the dynamics of a new Gene Regulatory Network model suggested by these discoveries we use mathematical modelling based on ordinary differential equations (ODEs). Our mathematical modelling of this Gene Regulatory Network reveals that a simplified model, with one "super-gene" for each class is sufficient to a large extent to describe the regulatory behaviour previously observed experimentally.

PubMed ID: 35934090
Article link: J Theor Biol
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: axin2l cdx2 chrd cntn1 frzb gsc lefty msx1 nodal sia1 wnt8a
GO keywords: Wnt signaling pathway

Article Images: [+] show captions