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Cell Rep 2022 Jul 19;403:111091. doi: 10.1016/j.celrep.2022.111091.
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Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition.

Hadjisavva R , Anastasiou O , Ioannou PS , Zheltkova M , Skourides PA .

Cadherins and integrins are intrinsically linked through the actin cytoskeleton and are largely responsible for the mechanical integrity and organization of tissues. We show that cadherin clustering stimulates and spatially guides integrin activation. Adherens junction (AJ)-associated integrin activation depends on locally generated tension and does not require extracellular matrix ligands. It leads to the creation of primed integrin clusters, which spatially determine where focal adhesions will form if ligands are present and where ligands will be deposited. AJs that display integrin activation are targeted by microtubules facilitating their disassembly via caveolin-based endocytosis, showing that integrin activation impacts the stability of the core cadherin complex. Thus, the interplay between cadherins and integrins is more intimate than what was once believed and is rooted in the capacity of active integrins to be stabilized via AJ-generated tension. Altogether, our data establish a mechanism of cross-regulation between cadherins and integrins.

PubMed ID: 35858563
Article link: Cell Rep

Species referenced: Xenopus laevis
Genes referenced: fn1 ilk ptk2 pxn
GO keywords: adherens junction [+]
Morpholinos: itgb1 MO1

Article Images: [+] show captions