Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-59019
Methods Mol Biol 2022 Jan 01;2438:83-95. doi: 10.1007/978-1-0716-2035-9_5.
Show Gene links Show Anatomy links

Biochemical Assays to Detect Activation of Small GTPases Rho, Rac, and Cdc42 during Morphogenesis.

Berns ML , Habas R .


Abstract
Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes through several distinct pathways. Wnt/Fz activation of the small GTPases Rho, Rac, and Cdc42, is one key mechanism that regulates cell polarity and migration during vertebrate gastrulation. In this chapter, we describe biochemical assays for detection of Wnt/Fz-mediated activation of Rho, Rac and Cdc42 in both mammalian cells and Xenopus embryo explants.

PubMed ID: 35147936
Article link: Methods Mol Biol


Genes referenced: cdc42 rac1 rho

References [+] :
Mardilovich, Targeting Rho GTPase signaling for cancer therapy. 2012, Pubmed