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Methods Mol Biol 2022 Jan 01;2438:83-95. doi: 10.1007/978-1-0716-2035-9_5.
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Biochemical Assays to Detect Activation of Small GTPases Rho, Rac, and Cdc42 during Morphogenesis.

Berns ML , Habas R .

Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes through several distinct pathways. Wnt/Fz activation of the small GTPases Rho, Rac, and Cdc42, is one key mechanism that regulates cell polarity and migration during vertebrate gastrulation. In this chapter, we describe biochemical assays for detection of Wnt/Fz-mediated activation of Rho, Rac and Cdc42 in both mammalian cells and Xenopus embryo explants.

PubMed ID: 35147936
Article link: Methods Mol Biol

Genes referenced: cdc42 rac1 rho

References [+] :
Mardilovich, Targeting Rho GTPase signaling for cancer therapy. 2012, Pubmed