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The neural crest is a highly migratory cell population that evolved in vertebrates. Born at the lateral borders of the neural plate, neural crest cells migrate long distances along defined paths and contribute to the development of many tissue and structures. Neural crest has become an important model for studying directional cell migration. Frog Xenopus laevis is particularly feasible in these studies. Both in vivo and in vitro analyses are performed to study frog neural crest cell migration. While in vivo analysis can provide direct knowledge of how neural crest cells interact with neighboring tissues during their migration, in vitro analysis can produce high-resolution results on cell morphological changes and cell motility. Here we provide a detailed protocol for performing quantitative analysis of Xenopus laevis neural crest cell migration in vitro.
Betancur,
Assembling neural crest regulatory circuits into a gene regulatory network.
2010, Pubmed
Betancur,
Assembling neural crest regulatory circuits into a gene regulatory network.
2010,
Pubmed
Carmona-Fontaine,
Contact inhibition of locomotion in vivo controls neural crest directional migration.
2008,
Pubmed
,
Xenbase
Carmona-Fontaine,
Complement fragment C3a controls mutual cell attraction during collective cell migration.
2011,
Pubmed
,
Xenbase
Dupin,
The contribution of the neural crest to the vertebrate body.
2006,
Pubmed
Dupin,
The issue of the multipotency of the neural crest cells.
2018,
Pubmed
Erickson,
Neural crest development: the interplay between morphogenesis and cell differentiation.
1998,
Pubmed
Kulesa,
Cranial neural crest migration: new rules for an old road.
2010,
Pubmed
Le Douarin,
The ontogeny of the neural crest in avian embryo chimaeras.
1980,
Pubmed
Sasselli,
The enteric nervous system.
2012,
Pubmed
Sater,
Induction of neuronal differentiation by planar signals in Xenopus embryos.
1993,
Pubmed
,
Xenbase
Szabó,
In vivo confinement promotes collective migration of neural crest cells.
2016,
Pubmed
,
Xenbase
Theveneau,
Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration.
2012,
Pubmed
,
Xenbase
Theveneau,
Chase-and-run between adjacent cell populations promotes directional collective migration.
2013,
Pubmed
Theveneau,
Neural crest migration: interplay between chemorepellents, chemoattractants, contact inhibition, epithelial-mesenchymal transition, and collective cell migration.
2012,
Pubmed
Trainor,
Specification of neural crest cell formation and migration in mouse embryos.
2005,
Pubmed
Wynn,
Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
2013,
Pubmed
