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Semin Cell Dev Biol 2023 Jan 15;133:53-64. doi: 10.1016/j.semcdb.2022.02.002.
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Regulation of organelle size and organization during development.

Chen P , Levy DL .

During early embryogenesis, as cells divide in the developing embryo, the size of intracellular organelles generally decreases to scale with the decrease in overall cell size. Organelle size scaling is thought to be important to establish and maintain proper cellular function, and defective scaling may lead to impaired development and disease. However, how the cell regulates organelle size and organization are largely unanswered questions. In this review, we summarize the process of size scaling at both the cell and organelle levels and discuss recently discovered mechanisms that regulate this process during early embryogenesis. In addition, we describe how some recently developed techniques and Xenopus as an animal model can be used to investigate the underlying mechanisms of size regulation and to uncover the significance of proper organelle size scaling and organization.

PubMed ID: 35148938
PMC ID: PMC9357868
Article link: Semin Cell Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
GO keywords: nucleus [+]

References [+] :
Acebron, Mitotic wnt signaling promotes protein stabilization and regulates cell size. 2014, Pubmed