Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Adv Sci (Weinh)
2022 Jan 01;93:e2103132. doi: 10.1002/advs.202103132.
Show Gene links
Show Anatomy links
Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M-Type Voltage-Gated Potassium Channels.
Abdullaeva OS
,
Sahalianov I
,
Silverå Ejneby M
,
Jakešová M
,
Zozoulenko I
,
Liin SI
,
Głowacki ED
.
???displayArticle.abstract???
H2 O2 plays a significant role in a range of physiological processes where it performs vital tasks in redox signaling. The sensitivity of many biological pathways to H2 O2 opens up a unique direction in the development of bioelectronics devices to control levels of reactive-oxygen species (ROS). Here a microfabricated ROS modulation device that relies on controlled faradaic reactions is presented. A concentric pixel arrangement of a peroxide-evolving cathode surrounded by an anode ring which decomposes the peroxide, resulting in localized peroxide delivery is reported. The conducting polymer (poly(3,4-ethylenedioxythiophene) (PEDOT), is exploited as the cathode. PEDOT selectively catalyzes the oxygen reduction reaction resulting in the production of hydrogen peroxide (H2 O2 ). Using electrochemical and optical assays, combined with modeling, the performance of the devices is benchmarked. The concentric pixels generate tunable gradients of peroxide and oxygen concentrations. The faradaic devices are prototyped by modulating human H2 O2 -sensitive Kv7.2/7.3 (M-type) channels expressed in a single-cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating neuronal excitability in the heart, brain, and smooth muscles, making it an ideal platform for faradaic ROS stimulation. The results demonstrate the potential of PEDOT to act as an H2 O2 delivery system, paving the way to ROS-based organic bioelectronics.
850622 European Union's Horizon 2020 research and innovation program, 949191 European Union's Horizon 2020 research and innovation program, Knut and Alice Wallenberg Foundation, European Research Council
Abd-Elsayed,
Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain.
2019, Pubmed
Abd-Elsayed,
Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain.
2019,
Pubmed
Abdel Aziz,
Light-Triggered Electron Transfer between a Conjugated Polymer and Cytochrome C for Optical Modulation of Redox Signaling.
2020,
Pubmed
Antognazza,
Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes.
2019,
Pubmed
Barrese,
KCNQ-Encoded Potassium Channels as Therapeutic Targets.
2018,
Pubmed
Bienert,
Membrane transport of hydrogen peroxide.
2006,
Pubmed
Cooper,
Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.
2000,
Pubmed
D'Autréaux,
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis.
2007,
Pubmed
Di Meo,
Role of ROS and RNS Sources in Physiological and Pathological Conditions.
2016,
Pubmed
Esin,
Neuropathic cancer pain: What we are dealing with? How to manage it?
2014,
Pubmed
Forman,
An overview of mechanisms of redox signaling.
2014,
Pubmed
Forman,
Signaling functions of reactive oxygen species.
2010,
Pubmed
Gamper,
Redox and nitric oxide-mediated regulation of sensory neuron ion channel function.
2015,
Pubmed
Gamper,
Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing.
2006,
Pubmed
Genestra,
Oxyl radicals, redox-sensitive signalling cascades and antioxidants.
2007,
Pubmed
Glorieux,
Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach.
2017,
Pubmed
Greene,
Modulation of Kv7 channels and excitability in the brain.
2017,
Pubmed
Gryszel,
General Observation of Photocatalytic Oxygen Reduction to Hydrogen Peroxide by Organic Semiconductor Thin Films and Colloidal Crystals.
2018,
Pubmed
Gryszel,
Organic thin film photofaradaic pixels for on-demand electrochemistry in physiological conditions.
2020,
Pubmed
Holmström,
Cellular mechanisms and physiological consequences of redox-dependent signalling.
2014,
Pubmed
Jakešová,
Optoelectronic control of single cells using organic photocapacitors.
2019,
Pubmed
,
Xenbase
Josephy,
The horseradish peroxidase-catalyzed oxidation of 3,5,3',5'-tetramethylbenzidine. Free radical and charge-transfer complex intermediates.
1982,
Pubmed
Lodola,
Conjugated polymers optically regulate the fate of endothelial colony-forming cells.
2019,
Pubmed
Miceli,
Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites.
2018,
Pubmed
Nappi,
Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction.
2020,
Pubmed
Park,
In situ electrochemical generation of nitric oxide for neuronal modulation.
2020,
Pubmed
Phillips,
Gold-Decorated Silicon Nanowire Photocatalysts for Intracellular Production of Hydrogen Peroxide.
2021,
Pubmed
Plauck,
Active sites and mechanisms for H₂O₂ decomposition over Pd catalysts.
2016,
Pubmed
Rabl,
Are Polyaniline and Polypyrrole Electrocatalysts for Oxygen (O2) Reduction to Hydrogen Peroxide (H2O2)?
2020,
Pubmed
Rhee,
Redox signaling: hydrogen peroxide as intracellular messenger.
1999,
Pubmed
Rivera-Arconada,
Enhancing m currents: a way out for neuropathic pain?
2009,
Pubmed
Roy,
Physiological role of reactive oxygen species as promoters of natural defenses.
2017,
Pubmed
Sahoo,
Oxidative modulation of voltage-gated potassium channels.
2014,
Pubmed
Sies,
Oxidative Stress.
2017,
Pubmed
Sies,
The steady state level of catalase compound I in isolated hemoglobin-free perfused rat liver.
1970,
Pubmed
Sies,
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.
2017,
Pubmed
Sies,
Role of metabolic H2O2 generation: redox signaling and oxidative stress.
2014,
Pubmed
Suzuki,
Oxidants as stimulators of signal transduction.
1997,
Pubmed
Wadnerkar,
Density Functional Theory Mechanistic Study on H2O2 Production Using an Organic Semiconductor Epindolidione.
2020,
Pubmed
Wang,
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
1998,
Pubmed
,
Xenbase
Warczak,
Organic semiconductor perylenetetracarboxylic diimide (PTCDI) electrodes for electrocatalytic reduction of oxygen to hydrogen peroxide.
2018,
Pubmed
Winterbourn,
Biological Production, Detection, and Fate of Hydrogen Peroxide.
2018,
Pubmed
