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Genetics
2022 May 05;2211:. doi: 10.1093/genetics/iyac049.
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Noggin proteins are multifunctional extracellular regulators of cell signaling.
Karunaraj P
,
Tidswell O
,
Duncan EJ
,
Lovegrove MR
,
Jefferies G
,
Johnson TK
,
Beck CW
,
Dearden PK
.
???displayArticle.abstract??? Noggin is an extracellular cysteine knot protein that plays a crucial role in vertebrate dorsoventral patterning. Noggin binds and inhibits the activity of bone morphogenetic proteins via a conserved N-terminal clip domain. Noncanonical orthologs of Noggin that lack a clip domain ("Noggin-like" proteins) are encoded in many arthropod genomes and are thought to have evolved into receptor tyrosine kinase ligands that promote Torso/receptor tyrosine kinase signaling rather than inhibiting bone morphogenic protein signaling. Here, we examined the molecular function of noggin/noggin-like genes (ApNL1 and ApNL2) from the arthropod pea aphid using the dorso-ventral patterning of Xenopus and the terminal patterning system of Drosophila to identify whether these proteins function as bone morphogenic protein or receptor tyrosine kinase signaling regulators. Our findings reveal that ApNL1 from the pea aphid can regulate both bone morphogenic protein and receptor tyrosine kinase signaling pathways, and unexpectedly, that the clip domain is not essential for its antagonism of bone morphogenic protein signaling. Our findings indicate that ancestral noggin/noggin-like genes were multifunctional regulators of signaling that have specialized to regulate multiple cell signaling pathways during the evolution of animals.
Ariizumi,
In Vitro Induction of Xenopus Embryonic Organs Using Animal Cap Cells.
2017, Pubmed,
Xenbase
Ariizumi,
In Vitro Induction of Xenopus Embryonic Organs Using Animal Cap Cells.
2017,
Pubmed
,
Xenbase
Ariizumi,
Isolation and differentiation of Xenopus animal cap cells.
2009,
Pubmed
,
Xenbase
Avsian-Kretchmer,
Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists.
2004,
Pubmed
Babonis,
Phylogenetic evidence for the modular evolution of metazoan signalling pathways.
2017,
Pubmed
Beck,
Gut specific expression using mammalian promoters in transgenic Xenopus laevis.
1999,
Pubmed
,
Xenbase
Bernatik,
A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.
2017,
Pubmed
Carroll,
Chance and necessity: the evolution of morphological complexity and diversity.
2001,
Pubmed
Casali,
The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo.
2001,
Pubmed
Casanova,
Pattern formation under the control of the terminal system in the Drosophila embryo.
1990,
Pubmed
Choi,
Mapping a multiplexed zoo of mRNA expression.
2016,
Pubmed
Cordenonsi,
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
2007,
Pubmed
,
Xenbase
Duncan,
Canonical terminal patterning is an evolutionary novelty.
2013,
Pubmed
Eroshkin,
Noggin4 is a long-range inhibitor of Wnt8 signalling that regulates head development in Xenopus laevis.
2016,
Pubmed
,
Xenbase
Fang,
Ectopic expression of Xenopus noggin RNA induces complete secondary body axes in embryos of the direct developing frog Eleutherodactylus coqui.
2000,
Pubmed
,
Xenbase
Furriols,
In and out of Torso RTK signalling.
2003,
Pubmed
Glinka,
Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus.
1997,
Pubmed
,
Xenbase
Gotoh,
Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
1995,
Pubmed
,
Xenbase
Groppe,
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.
2002,
Pubmed
Henstridge,
Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like.
2014,
Pubmed
Hill,
TGF-beta signalling pathways in early Xenopus development.
2001,
Pubmed
,
Xenbase
Holley,
The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.
1996,
Pubmed
,
Xenbase
Kao,
The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos.
1988,
Pubmed
,
Xenbase
Kawabata,
Signal transduction by bone morphogenetic proteins.
1998,
Pubmed
LaBonne,
Mesoderm induction by activin requires FGF-mediated intracellular signals.
1994,
Pubmed
,
Xenbase
Lamb,
Neural induction by the secreted polypeptide noggin.
1993,
Pubmed
,
Xenbase
Lu,
The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction.
1993,
Pubmed
Luo,
Immunostaining of germline stem cells and the niche in Drosophila ovaries.
2013,
Pubmed
Massagué,
The logic of TGFbeta signaling.
2006,
Pubmed
McBrayer,
Prothoracicotropic hormone regulates developmental timing and body size in Drosophila.
2007,
Pubmed
Molina,
Noggin and noggin-like genes control dorsoventral axis regeneration in planarians.
2011,
Pubmed
,
Xenbase
Nagata,
A novel type of receptor cDNA from the prothoracic glands of the silkworm, Bombyx mori.
2006,
Pubmed
Pires-daSilva,
The evolution of signalling pathways in animal development.
2003,
Pubmed
Reilly,
Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction.
1996,
Pubmed
,
Xenbase
Reversade,
Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.
2005,
Pubmed
,
Xenbase
Rewitz,
The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis.
2009,
Pubmed
Rokas,
The origins of multicellularity and the early history of the genetic toolkit for animal development.
2008,
Pubmed
Sakata,
Nkx2.5 is involved in myeloid cell differentiation at anterior ventral blood islands in the Xenopus embryo.
2014,
Pubmed
,
Xenbase
Shigenobu,
Comprehensive survey of developmental genes in the pea aphid, Acyrthosiphon pisum: frequent lineage-specific duplications and losses of developmental genes.
2010,
Pubmed
Skelly,
Evolution of the Torso activation cassette, a pathway required for terminal patterning and moulting.
2019,
Pubmed
Smith,
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.
1992,
Pubmed
,
Xenbase
Smith,
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm.
1993,
Pubmed
,
Xenbase
Stevens,
Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo.
1990,
Pubmed
Twombly,
The TGF-beta signaling pathway is essential for Drosophila oogenesis.
1996,
Pubmed
Umbhauer,
Mesoderm induction in Xenopus caused by activation of MAP kinase.
1995,
Pubmed
,
Xenbase
Wang,
Genetics of nanos localization in Drosophila.
1994,
Pubmed
YAMADA,
A technique for testing macromolecular samples in solution for morphogenetic effects on the isolated ectoderm of the amphibian gastrula.
1961,
Pubmed
Yamanaka,
Neuropeptide receptor transcriptome reveals unidentified neuroendocrine pathways.
2008,
Pubmed
Zimmerman,
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
1996,
Pubmed
,
Xenbase