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Animals (Basel) 2022 Apr 06;127:. doi: 10.3390/ani12070937.
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Bisphenol A Interferes with Redox Balance and the Nrf2 Signaling Pathway in Xenopus tropicalis during Embryonic Development.

Chen H , Zhong K , Zhang Y , Xie L , Chen P .

Bisphenol A (BPA), an environmental estrogen, is widely used and largely released into the hydrosphere, thus inducing adverse effects in aquatic organisms. Here, Xenopus tropicalis was used as an animal model to investigate the oxidative effects of BPA on early embryonic development. BPA exposure prevalently caused development delay and shortened body length. Furthermore, BPA exposure significantly increased the levels of reactive oxygen species (ROS) and DNA damage in embryos. Thus, the details of BPA interference with antioxidant regulatory pathways during frog early embryonic development should be further explored.

PubMed ID: 35405925
Article link: Animals (Basel)
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: gabpa

References [+] :
Abebe, Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress. 2017, Pubmed