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Dev Cell 2022 May 09;579:1119-1131.e5. doi: 10.1016/j.devcel.2022.04.001.
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ARVCF catenin controls force production during vertebrate convergent extension.

Huebner RJ , Weng S , Lee C , Sarıkaya S , Papoulas O , Cox RM , Marcotte EM , Wallingford JB .

The design of an animal's body plan is encoded in the genome, and the execution of this program is a mechanical progression involving coordinated movement of proteins, cells, and whole tissues. Thus, a challenge to understanding morphogenesis is connecting events that occur across various length scales. Here, we describe how a poorly characterized adhesion effector, Arvcf catenin, controls Xenopus head-to-tail axis extension. We find that Arvcf is required for axis extension within the intact organism but not within isolated tissues. We show that the organism-scale phenotype results from a defect in tissue-scale force production. Finally, we determine that the force defect results from the dampening of the pulsatile recruitment of cell adhesion and cytoskeletal proteins to membranes. These results provide a comprehensive understanding of Arvcf function during axis extension and produce an insight into how a cellular-scale defect in adhesion results in an organism-scale failure of development.

PubMed ID: 35476939
PMC ID: PMC9308970
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: arvcf cdh3 ctnna1 not
GO keywords: cell adhesion [+]
Antibodies: Cdh3 Ab1 Ctnna1 Ab1
Morpholinos: arvcf MO1

Article Images: [+] show captions
References [+] :
Aktary, Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis. 2017, Pubmed