XB-ART-58840
Nucleosides Nucleotides Nucleic Acids
2022 Jan 01;4112:1279-1286. doi: 10.1080/15257770.2022.2028826.
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SLC23A3 is a renal hypoxanthine transporter.
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LLC-PK1 renal cells show Na+-dependent and Na+-independent hypoxanthine uptake. While the latter is inhibited by adenine, neither are inhibited by xanthine. In rats, intestinal Na+-dependent hypoxanthine transporter Slc23a4 is not expressed in the kidney, and its action is inhibited by xanthine. This study aimed to clone Slc23a4-paralog SLC23A3 from the human kidney and investigate its hypoxanthine transport activity. We observed Na+-dependent 10 nM [3H]-hypoxanthine uptake in SLC23A3 RNA-injected Xenopus oocytes. Moreover, 100 μM xanthine did not inhibit Na+-independent 300 nM [3H]-hypoxanthine uptake, whereas 100 μM adenine did. These results confirm that SLC23A3 is a hypoxanthine transporter in the human kidney.
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Species referenced: Xenopus laevis
Genes referenced: pklr slc23a3
GO keywords: renal sodium ion transport