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Phys Rev Lett 2021 Nov 05;12719:198102. doi: 10.1103/PhysRevLett.127.198102.
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Fluid Mechanics of Mosaic Ciliated Tissues.

Boselli F , Jullien J , Lauga E , Goldstein RE .

In tissues as diverse as amphibian skin and the human airway, the cilia that propel fluid are grouped in sparsely distributed multiciliated cells (MCCs). We investigate fluid transport in this "mosaic" architecture, with emphasis on the trade-offs that may have been responsible for its evolutionary selection. Live imaging of MCCs in embryos of the frog Xenopus laevis shows that cilia bundles behave as active vortices that produce a flow field accurately represented by a local force applied to the fluid. A coarse-grained model that self-consistently couples bundles to the ambient flow reveals that hydrodynamic interactions between MCCs limit their rate of work so that they best shear the tissue at a finite but low area coverage, a result that mirrors findings for other sparse distributions such as cell receptors and leaf stomata.

PubMed ID: 34797132
Article link: Phys Rev Lett
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: mcc

Article Images: [+] show captions