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J Dev Biol 2021 Aug 27;93:. doi: 10.3390/jdb9030034.
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The Role of RNA-Binding Proteins in Vertebrate Neural Crest and Craniofacial Development.

Forman TE , Dennison BJC , Fantauzzo KA .

Cranial neural crest (NC) cells delaminate from the neural folds in the forebrain to the hindbrain during mammalian embryogenesis and migrate into the frontonasal prominence and pharyngeal arches. These cells generate the bone and cartilage of the frontonasal skeleton, among other diverse derivatives. RNA-binding proteins (RBPs) have emerged as critical regulators of NC and craniofacial development in mammals. Conventional RBPs bind to specific sequence and/or structural motifs in a target RNA via one or more RNA-binding domains to regulate multiple aspects of RNA metabolism and ultimately affect gene expression. In this review, we discuss the roles of RBPs other than core spliceosome components during human and mouse NC and craniofacial development. Where applicable, we review data on these same RBPs from additional vertebrate species, including chicken, Xenopus and zebrafish models. Knockdown or ablation of several RBPs discussed here results in altered expression of transcripts encoding components of developmental signaling pathways, as well as reduced cell proliferation and/or increased cell death, indicating that these are common mechanisms contributing to the observed phenotypes. The study of these proteins offers a relatively untapped opportunity to provide significant insight into the mechanisms underlying gene expression regulation during craniofacial morphogenesis.

PubMed ID: 34564083
Article link: J Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cnbp col2a1 ddx3x dlx2 eif4a3.1 elavl1 elavl4 esrp1 fam50a foxd3 hnrnpk hnrnpu ptbp1 rbfox2 rbmx sox9 srsf3 tbx2 tcof1 tfap2a
GO keywords: neural crest cell migration [+]

Disease Ontology terms: nonsyndromic deafness [+]

Article Images: [+] show captions
References [+] :
Abe, CNBP regulates forebrain formation at organogenesis stage in chick embryos. 2006, Pubmed