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FEBS Lett 2021 Nov 01;59521:2655-2664. doi: 10.1002/1873-3468.14195.
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3-phosphoinositide-dependent protein kinase 1 (PDK1) mediates crosstalk between Src and Akt pathways in MET receptor signaling.

Molinaro C , Martoriati A , Lescuyer A , Fliniaux I , Tulasne D , Cailliau K .

The high-affinity tyrosine kinase receptor MET plays a pivotal role in several facets of cell regulation. Although its mitogenic effect is well documented, some aspects of connection patterns between signaling pathways involved in cell cycle progression remain to be deciphered. We have used a tractable heterologous expression system, the Xenopus oocyte, to detect connections between distinct MET signaling cascades involved in G2/M progression. Our results reveal that Src acts as an adapter via its SH2 domain to recruit 3-phosphoinositide-dependent protein kinase 1 (PDK1) to the MET signaling complex leading to Akt phosphorylation. These data define an original crosstalk between Src and Akt signaling pathways that contributes to MET-induced entry into the M phase, and deserves further investigation in pathologies harboring deregulation of this receptor.

PubMed ID: 34551132
Article link: FEBS Lett

Species referenced: Xenopus laevis
Genes referenced: met pdk1 src
GO keywords: 3-phosphoinositide-dependent protein kinase activity [+]