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Dev Dyn 2022 Mar 01;2513:498-512. doi: 10.1002/dvdy.420.
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Anterior patterning genes induced by Zic1 are sensitive to retinoic acid and its metabolite, 4-oxo-RA.

Dubey A , Saint-Jeannet JP .

BACKGROUND: Development of paired sensory organs is a highly complex and coordinated process. These organs arise from ectodermal thickenings in the cephalic region known as cranial placodes. We have previously shown that Zic1 is a critical regulator for the formation of the pre-placodal region (PPR), the common territory for the development of all cranial placodes in Xenopus laevis. RESULTS: In this study, we have analyzed a number of Zic1 targets for their expression during PPR patterning, as well as their regulation by retinoic acid (RA) and one of its major metabolites, 4-oxo-RA. Our findings show that anteriorly Zic1 regulates several transcription factors, Crx, Fezf2, Nkx3-1, and Xanf1 as well as a serine/threonine/tyrosine kinase, Pkdcc.2. These factors are all expressed in the vicinity of the PPR and as such are candidate regulators of placode formation downstream of Zic1. In addition to their differential regulation by RA, we find that 4-oxo-RA is also capable of modulating the expression of these genes, as well as a broad array of RA-regulated genes. CONCLUSION: Our data highlight the complexity of retinoid-mediated regulation required for Zic1-activated anterior structure specification in Xenopus, and the potential physiological role of 4-oxo-RA in cranial placode development.

PubMed ID: 34536327
PMC ID: PMC8891028
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: crx fezf2 hesx1 nkx3-1 pkdcc.2 zic1
GO keywords: retinoic acid receptor signaling pathway

GEO Series: GSE180269: NCBI
References [+] :
Achkar, 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. 1996, Pubmed, Xenbase