Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-58347
Biol Open 2021 Jul 15;107:. doi: 10.1242/bio.058761.
Show Gene links Show Anatomy links

The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate.

Mancini P , Ossipova O , Sokol SY .


Abstract
Coordinated polarization of cells in the tissue plane, known as planar cell polarity (PCP), is associated with a signaling pathway critical for the control of morphogenetic processes. Although the segregation of PCP components to opposite cell borders is believed to play a critical role in this pathway, whether PCP derives from egg polarity or preexistent long-range gradient, or forms in response to a localized cue, remains a challenging question. Here we investigate the Xenopus neural plate, a tissue that has been previously shown to exhibit PCP. By imaging Vangl2 and Prickle3, we show that PCP is progressively acquired in the neural plate and requires a signal from the posterior region of the embryo. Tissue transplantations indicated that PCP is triggered in the neural plate by a planar cue from the dorsal blastopore lip. The PCP cue did not depend on the orientation of the graft and was distinct from neural inducers. These observations suggest that neuroectodermal PCP is not instructed by a preexisting molecular gradient but induced by a signal from the dorsal blastopore lip.

PubMed ID: 34259326
Article link: Biol Open
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: frzb2 mcf2 nps prickle3 sox3 vangl2
GO keywords: establishment of planar polarity [+]
Antibodies: GFP Ab7 Vangl2 Ab2


Article Images: [+] show captions
References [+] :
Aigouy, Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. 2010, Pubmed