Walentek P .

K99 HL127275 NHLBI NIH HHS

                lung disease

Abdullah, Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. 2017, Pubmed

Abdullah, Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. 2017, Pubmed
Alyass, From big data analysis to personalized medicine for all: challenges and opportunities. 2015, Pubmed
Ambort, Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. 2012, Pubmed
Arason, deltaNp63 has a role in maintaining epithelial integrity in airway epithelium. 2014, Pubmed
Aros, High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. 2020, Pubmed
Aros, Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging. 2020, Pubmed
Baarsma, 'WNT-er is coming': WNT signalling in chronic lung diseases. 2017, Pubmed
Ballweg, Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells. 2014, Pubmed
Belgacemi, Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD. 2020, Pubmed
Bilodeau, Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential. 2014, Pubmed
Brooks, Multiciliated cells. 2014, Pubmed
Caron, Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. 2012, Pubmed
Chen, SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. 2009, Pubmed
Chen, Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice. 2018, Pubmed
Cibois, BMP signalling controls the construction of vertebrate mucociliary epithelia. 2015, Pubmed , Xenbase
Clevers, Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. 2014, Pubmed
Collins, Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells. 2021, Pubmed , Xenbase
Corfield, Mucins: a biologically relevant glycan barrier in mucosal protection. 2015, Pubmed
Cutz, Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors. 2013, Pubmed
Danahay, Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. 2015, Pubmed
Daniely, Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. 2004, Pubmed
Danopoulos, FGF Signaling in Lung Development and Disease: Human Versus Mouse. 2019, Pubmed
Deblandre, A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryos. 1999, Pubmed , Xenbase
Dobzanski, Nasal polyp fibroblasts modulate epithelial characteristics via Wnt signaling. 2018, Pubmed
Doran, Effect of serotonin on ciliary beating and intracellular calcium concentration in identified populations of embryonic ciliary cells. 2004, Pubmed
Driskell, Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. 2004, Pubmed
Driskell, Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. 2007, Pubmed
Dubaissi, A 'tad' of hope in the fight against airway disease. 2020, Pubmed , Xenbase
Dubaissi, A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis. 2014, Pubmed , Xenbase
Dutko, SnapShot: BMP signaling in development. 2011, Pubmed
Evans, Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. 2004, Pubmed
Fahy, Airway mucus function and dysfunction. 2010, Pubmed
Frank, Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. 2016, Pubmed
Giaimo, Dynamic chromatin regulation at Notch target genes. 2017, Pubmed
Goldfarbmuren, Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium. 2020, Pubmed
Gomi, Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. 2015, Pubmed
Gomperts, IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. 2007, Pubmed
Graff, Cigarette smoking decreases global microRNA expression in human alveolar macrophages. 2012, Pubmed
GURDON, The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. 1962, Pubmed , Xenbase
Guseh, Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. 2009, Pubmed
Haas, ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia. 2019, Pubmed , Xenbase
He, Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients. 2020, Pubmed
Heijink, Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease. 2013, Pubmed
Henrique, Mechanisms of Notch signaling: a simple logic deployed in time and space. 2019, Pubmed
Hogan, Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 2014, Pubmed
Hou, Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. 2019, Pubmed
Hoyer, Risk factors for diagnostic delay in idiopathic pulmonary fibrosis. 2019, Pubmed
Hu, Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. 2020, Pubmed
Huang, Polarized Wnt signaling regulates ectodermal cell fate in Xenopus. 2014, Pubmed , Xenbase
Huang, Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. 2014, Pubmed
Huang, The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. 2015, Pubmed
Ibañez-Tallon, To beat or not to beat: roles of cilia in development and disease. 2003, Pubmed
Kim, WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. 2019, Pubmed
Kjolby, Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation. 2017, Pubmed , Xenbase
König, Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea. 2009, Pubmed
Kurrle, Serotonin and MucXS release by small secretory cells depend on Xpod, a SSC specific marker gene. 2020, Pubmed , Xenbase
Lafkas, Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung. 2015, Pubmed
Lake, RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. 2014, Pubmed
Lehmann, WNT Signaling in Lung Aging and Disease. 2016, Pubmed
Lynch, Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. 2018, Pubmed
Macdonald, SnapShot: Wnt/beta-catenin signaling. 2007, Pubmed
McCormack, Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium. 2013, Pubmed
Méndez, Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways. 2019, Pubmed
Merrell, Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style. 2016, Pubmed
Meunier, Multiciliated Cells in Animals. 2016, Pubmed
Mitchison, Motile and non-motile cilia in human pathology: from function to phenotypes. 2017, Pubmed
Molloy, BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells. 2008, Pubmed
Montoro, A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. 2018, Pubmed
Morimoto, Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. 2012, Pubmed
Mou, Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 2016, Pubmed
Mucenski, Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. 2005, Pubmed
Mukherjee, Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. 2007, Pubmed
Naylor, Unraveling human complexity and disease with systems biology and personalized medicine. 2010, Pubmed
Nishikawa, Fate of ciliated epidermal cells during early development of Xenopus laevis using whole-mount immunostaining with an antibody against chondroitin 6-sulfate proteoglycan and anti-tubulin: transdifferentiation or metaplasia of amphibian epidermis. 1992, Pubmed , Xenbase
Pardo-Saganta, Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge. 2013, Pubmed
Pardo-Saganta, Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. 2015, Pubmed
Pardo-Saganta, Parent stem cells can serve as niches for their daughter cells. 2015, Pubmed
Parker, Chronic IL9 and IL-13 exposure leads to an altered differentiation of ciliated cells in a well-differentiated paediatric bronchial epithelial cell model. 2013, Pubmed
Peng, Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. 2015, Pubmed
Perrimon, Signaling mechanisms controlling cell fate and embryonic patterning. 2012, Pubmed
Plasschaert, A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. 2018, Pubmed
Quigley, Specification of ion transport cells in the Xenopus larval skin. 2011, Pubmed , Xenbase
Quigley, Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression. 2017, Pubmed , Xenbase
Rawlins, The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. 2009, Pubmed
Renz, Gene-environment interaction in chronic disease: a European Science Foundation Forward Look. 2011, Pubmed
Reynolds, Conditional stabilization of beta-catenin expands the pool of lung stem cells. 2008, Pubmed
Reynolds, Clara cell: progenitor for the bronchiolar epithelium. 2010, Pubmed
Rock, Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. 2010, Pubmed
Rock, Basal cells as stem cells of the mouse trachea and human airway epithelium. 2009, Pubmed
Rock, Notch-dependent differentiation of adult airway basal stem cells. 2011, Pubmed
Rokicki, The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases. 2016, Pubmed
Roy, The motile cilium in development and disease: emerging new insights. 2009, Pubmed
Ruiz García, Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures. 2019, Pubmed
Ruptier, TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression. 2011, Pubmed
Sanz-Ezquerro, Editorial: Signaling Pathways in Embryonic Development. 2017, Pubmed
Schamberger, Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-β. 2014, Pubmed
Schamberger, Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface. 2015, Pubmed
Schmid, Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways. 2017, Pubmed
Sears, Environmental determinants of chronic disease and medical approaches: recognition, avoidance, supportive therapy, and detoxification. 2012, Pubmed
Semenov, SnapShot: Noncanonical Wnt Signaling Pathways. 2007, Pubmed
Senoo, p63 Is essential for the proliferative potential of stem cells in stratified epithelia. 2007, Pubmed
Shi, Distinct Roles of Wnt/β-Catenin Signaling in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. 2017, Pubmed
Sirour, Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway. 2011, Pubmed , Xenbase
Smith, Diagnosis in chronic obstructive pulmonary disease-"Too little, too late?". 2015, Pubmed
Sountoulidis, Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair. 2012, Pubmed
Steinhart, Wnt signaling in development and tissue homeostasis. 2018, Pubmed
Stubbs, Radial intercalation of ciliated cells during Xenopus skin development. 2006, Pubmed , Xenbase
Sun, Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia. 2018, Pubmed , Xenbase
Tadokoro, BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 2016, Pubmed
Takahashi, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 2006, Pubmed
Tasca, Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling. 2021, Pubmed , Xenbase
Tata, Plasticity in the lung: making and breaking cell identity. 2017, Pubmed
Tata, Dedifferentiation of committed epithelial cells into stem cells in vivo. 2013, Pubmed
Tilley, Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. 2009, Pubmed
Tilley, Cilia dysfunction in lung disease. 2015, Pubmed
Tsao, Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. 2009, Pubmed
Turner, Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. 2011, Pubmed
Tyner, Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. 2006, Pubmed
Van Lommel, Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): chemoreceptors and regulators of lung development. 2001, Pubmed
van Rijt, Acute cigarette smoke exposure impairs proteasome function in the lung. 2012, Pubmed
Vladar, Dishevelled links basal body docking and orientation in ciliated epithelial cells. 2008, Pubmed , Xenbase
Vladar, Noncanonical Wnt planar cell polarity signaling in lung development and disease. 2020, Pubmed
Wagner, Mucins and Their Role in Shaping the Functions of Mucus Barriers. 2018, Pubmed
Walentek, A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles. 2014, Pubmed , Xenbase
Walentek, Manipulating and Analyzing Cell Type Composition of the Xenopus Mucociliary Epidermis. 2018, Pubmed , Xenbase
Walentek, What we can learn from a tadpole about ciliopathies and airway diseases: Using systems biology in Xenopus to study cilia and mucociliary epithelia. 2017, Pubmed , Xenbase
Walentek, ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development. 2012, Pubmed , Xenbase
Walentek, ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia. 2015, Pubmed , Xenbase
Wallingford, Planar cell polarity signaling, cilia and polarized ciliary beating. 2010, Pubmed
Walters, Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity. 2013, Pubmed
Wang, Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. 2011, Pubmed
Wang, MTOR Suppresses Cigarette Smoke-Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease. 2018, Pubmed
Wang, IL-4/IL-13 upregulates Sonic hedgehog expression to induce allergic airway epithelial remodeling. 2020, Pubmed
Wells, Diverse mechanisms for endogenous regeneration and repair in mammalian organs. 2018, Pubmed
Weng, Complexity in biological signaling systems. 1999, Pubmed
Williams, Airway mucus: From production to secretion. 2006, Pubmed
Xie, Sox2 modulates Lef-1 expression during airway submucosal gland development. 2014, Pubmed
Yu, Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells. 2010, Pubmed
Yuan, Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury. 2018, Pubmed
Zanin, The Interaction between Respiratory Pathogens and Mucus. 2016, Pubmed
Zariwala, The emerging genetics of primary ciliary dyskinesia. 2011, Pubmed
Zemke, beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. 2009, Pubmed
Zhang, Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro. 2014, Pubmed
Zuo, p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. 2015, Pubmed
Zuo, Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes. 2019, Pubmed
Zuo, Dysregulation of club cell biology in idiopathic pulmonary fibrosis. 2020, Pubmed