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Cell 2021 Apr 15; doi: 10.1016/j.cell.2021.02.034.
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Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer.

How are individual cell behaviors coordinated toward invariant large-scale anatomical outcomes in development and regeneration despite unpredictable perturbations? Endogenous distributions of membrane potentials, produced by ion channels and gap junctions, are present across all tissues. These bioelectrical networks process morphogenetic information that controls gene expression, enabling cell collectives to make decisions about large-scale growth and form. Recent progress in the analysis and computational modeling of developmental bioelectric circuits and channelopathies reveals how cellular collectives cooperate toward organ-level structural order. These advances suggest a roadmap for exploiting bioelectric signaling for interventions addressing developmental disorders, regenerative medicine, cancer reprogramming, and synthetic bioengineering.

PubMed ID: 33826908
Article link: Cell

Species referenced: Xenopus laevis
Genes referenced: arfgap1 atp4a churc1 gja1 hcn2 hcn4 kcnh2 kcnj12 kcnj2 kcnj8 kcnt1 notch1
GO keywords: ion channel activity [+]

Disease Ontology terms: Andersen-Tawil syndrome [+]

Article Images: [+] show captions