XB-ART-57843Dev Cell 2021 Feb 22;564:402-404. doi: 10.1016/j.devcel.2021.02.003.
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A not-so-simple twist of fate.
Multiciliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al. (2021) show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.
PubMed ID: 33621489
Article link: Dev Cell
Species referenced: Xenopus laevis
Genes referenced: notch1 twist1
GO keywords: tissue remodeling