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Int J Dev Biol 2021 Jan 01;654-5-6:227-233. doi: 10.1387/ijdb.200231ja.
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Establishing embryonic territories in the context of Wnt signaling.

Velloso I , Maia LA , Amado NG , Reis AH , He X , Abreu JG .

This review highlights the work that my research group has been developing, together with international collaborators, during the last decade. Since we were able to establish the Xenopus laevis experimental model in Brazil, we have been focused on understanding early embryonic patterns regarding neural induction and axes establishment. In this context, the Wnt pathway appears as a major player and has been much explored by us and other research groups. Here, we chose to review three published works which we consider to be landmarks within the course of our research and also within the history of modern findings regarding neural induction and patterning. We intend to show how our series of discoveries, when painted together, tells a story that covers crucial developmental windows of early differentiation paths of anterior neural tissue: 1. establishing the head organizer in contrast to the trunk organizer in the early gastrula; 2. deciding between neural ectoderm and epidermis ectoderm at the blastula/gastrula stages, and 3. the gathering of prechordal unique properties in the late gastrula/early neurula.

PubMed ID: 32930371
Article link: Int J Dev Biol

Species referenced: Xenopus laevis
Genes referenced: cer1 chrd ctnnb1 dkk1 dvl1 gsc gsk3b kremen1 lhx1 notum otx2 sox2 trabd2a
GO keywords: Wnt signaling pathway

Disease Ontology terms: familial adenomatous polyposis

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