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The tail of Xenopus tadpole is an excellent model for appendage regeneration studies. We analyzed the distribution pattern of the transcription factor Xvent-2 mRNA and protein in the beginning of the regeneration of Xenopus tadpoletail stumps after amputation. We revealed the emergence of Xvent-2 mRNA and protein in regeneration bud during the first day after amputation. The data obtained confirm that soon after amputation of the part of the Xenopus tadpoletail, there occurs the emergence of a structure, to some extend, resembling the early embryonic tail bud.
Figure 1 The spatial distribution of Xvent-2 protein and mRNA in the regenerating tails of Xenopus embryos. (A,B,C,D) Immunostaining; (E,F,G,H) in situ hybridization. A: 0 h; C: 6 h; D,E,F: 20 h after amputation; G,H: amputated tail parts; B: cross-section of the tail in the amputation area. Sections thickness about 0.2 mm. nc, notochord; sc, spinal cord; a, dorsal aorta; v, posterior cardinal vein; av, dorsal lateral anastomosing vessel; f, fin; H, control in situ hybridization with a sense probe. Scale bars: A–E,G,H, 500 µm; F, 100 µm.
Aztekin,
Identification of a regeneration-organizing cell in the Xenopus tail.
2019, Pubmed,
Xenbase
Aztekin,
Identification of a regeneration-organizing cell in the Xenopus tail.
2019,
Pubmed
,
Xenbase
Beck,
Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms.
2009,
Pubmed
,
Xenbase
Bronner,
Development and evolution of the neural crest: an overview.
2012,
Pubmed
,
Xenbase
Chang,
Transcriptional dynamics of tail regeneration in Xenopus tropicalis.
2017,
Pubmed
,
Xenbase
Chen,
Tadpole tail regeneration in Xenopus.
2014,
Pubmed
,
Xenbase
Henningfeld,
Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1.
2002,
Pubmed
,
Xenbase
Ho,
TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
2008,
Pubmed
,
Xenbase
Lehmann,
In situ hybridization to RNA.
1994,
Pubmed
Meulemans,
Gene-regulatory interactions in neural crest evolution and development.
2004,
Pubmed
Pshennikova,
[Neural Crest-An Unusual Population of Embryonic Cells].
2019,
Pubmed
Pshennikova,
The proteins of Vent-family and their mRNAs are located in different areas of the tails of Zebrafish and Xenopus embryos.
2016,
Pubmed
,
Xenbase
Sugiura,
Xenopus Wnt-5a induces an ectopic larval tail at injured site, suggesting a crucial role for noncanonical Wnt signal in tail regeneration.
2009,
Pubmed
,
Xenbase
Theveneau,
Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration.
2012,
Pubmed
,
Xenbase
