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Biochem Biophys Res Commun 2020 Jul 05;5274:896-901. doi: 10.1016/j.bbrc.2020.05.009.
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Dach1 regulates neural crest migration during embryonic development.

Kim YK , Lee H , Ismail T , Kim Y , Lee HS .

Dachshund 1(Dach1) is a key component of the retinal determination gene network that plays significant roles in cell fate regulation. The vertebrate homolog of Drosophila dachshund has gained considerable importance as an essential regulator of development, but its functions during embryonic development remain elusive. We investigated the functional significance of dach1 during Xenopus embryogenesis using loss-of-function studies. Reverse transcription-polymerase chain reaction demonstrated the maternal nature of dach1, showing enhanced expression at the neurula stage of development, and morpholino oligonucleotide injection of dach1 induced phenotypic anomalies of microcephaly and reduced body length. Animal cap assays followed by whole-mount in-situ hybridization indicated the perturbed expression of neural and neural crest (NC) markers. Our data suggest the prerequisite functions of dach1 in NC migration during Xenopus embryogenesis. However, the developmental pathways regulated by dach1 during embryogenesis require further elucidation.

PubMed ID: 32430182
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: ag1 dach1 egr2 en2 foxg1 hesx1 ncam1 odc1 otx2 pax3 six3 snai2 sox2 sox3 sox9 twist1 zic3
GO keywords: cell fate determination [+]
Morpholinos: dach1 MO1

Article Images: [+] show captions