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Gene Expr Patterns 2002 Dec 01;23-4:369-72. doi: 10.1016/s1567-133x(02)00023-6.
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Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus.

Pilcher KE , Krieg PA .

Signaling by the Wnt family of secreted growth factors is involved in numerous different aspects of embryonic development and also for maintenance of cellular function in adult tissues. In addition to regulation at the transcriptional level, Wnt activity is modulated by a number of different Wnt-binding proteins. Here we report the cloning and developmental expression pattern of the Xenopus orthologue of secreted Frizzled-related protein 5 (sFRP5), an endogenous inhibitor of Wnt signaling. At early stages of endodermal differentiation, sFRP5 is expressed in the developing liver. At later stages however, sFRP5 expression is down-regulated in the liver and becomes strongly expressed in the region corresponding to the junction between the posterior portion of the stomach and the anterior intestines.

PubMed ID: 12617827
Article link: Gene Expr Patterns
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cdx1 cdx2 hhex sfrp5 sox2

Article Images: [+] show captions