Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-56519
Gen Comp Endocrinol 2020 Feb 01;287:113349. doi: 10.1016/j.ygcen.2019.113349.
Show Gene links Show Anatomy links

Comprehensive RNA-Seq analysis of notochord-enriched genes induced during Xenopus tropicalis tail resorption.

Nakajima K , Tanizaki Y , Luu N , Zhang H , Shi YB .


Abstract
Anuran metamorphosis is perhaps the most dramatic developmental process regulated by thyroid hormone (TH). One of the unique processes that occur during metamorphosis is the complete resorption of the tail, including the notochord. Interestingly, recent gene knockout studies have shown that of the two known vertebrate TH receptors, TRα and TRβ, TRβ appears to be critical for notochord regression during tail resorption in Xenopus tropicalis. To determine the mechanisms underlying notochord regression, we carried out a comprehensive gene expression analysis in the notochord during metamorphosis by using RNA-Seq analyses of whole tail at stage 60 before any noticeable tail length reduction, whole tail at stage 63 when the tail length is reduced by about one half, and the rest of the tail at stage 63 after removing the notochord. This allowed us to identify many notochord-enriched, metamorphosis-induced genes at stage 63. Future studies on these genes should help to determine if they are regulated by TRβ and play any roles in notochord regression.

PubMed ID: 31794731
PMC ID: PMC6956247
Article link: Gen Comp Endocrinol
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: mmp1 mmp11 mmp13 mmp13l mmp14 mmp15 mmp16 mmp17 mmp19 mmp2 mmp20 mmp21 mmp23b mmp24 mmp25 mmp28 mmp3 mmp7 mmp8 mmp9.1 not olfm4 plin1
GO keywords: innate immune response in mucosa [+]

GEO Series: GSE133220: NCBI

Article Images: [+] show captions
References [+] :
Amano, Spatio-temporal regulation and cleavage by matrix metalloproteinase stromelysin-3 implicate a role for laminin receptor in intestinal remodeling during Xenopus laevis metamorphosis. 2005, Pubmed, Xenbase