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Pflugers Arch
2003 Feb 01;4455:601-6. doi: 10.1007/s00424-002-0982-y.
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Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.
Embark HM
,
Böhmer C
,
Vallon V
,
Luft F
,
Lang F
.
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The slowly activating K(+) channel subunit KCNE1 is expressed in a variety of tissues including proximal renal tubules, cardiac myocytes and stria vascularis of inner ear. The present study has been performed to explore whether the serum- and glucocorticoid-inducible kinase family members SGK1, SGK2, or SGK3 and/or protein kinase B (PKB) influence K(+) channel activity in Xenopus oocytes expressing KCNE1. cRNA encoding KCNE1 was injected with or without cRNA encoding wild-type SGK1, constitutively active (S422D)SGK1, inactive (K127 N)SGK1, wild-type SGK2, wild-type SGK3 or constitutively active (T308D,S473D)PKB. In oocytes injected with KCNE1 cRNA but not in water-injected oocytes a depolarization from -80 mV to -10 mV led to the appearance of a slowly activating K(+) current. Coexpression of SGK1,( S422D)SGK1, SGK2, SGK3 or (T308D,S473D)PKB but not (K127 N)SGK1 significantly stimulated KCNE1-induced current. The effect did not depend on Na(+)/K(+)-ATPase activity. KCNE1-induced current was markedly upregulated by coexpression of KCNQ1 and further increased by additional expression of (S422D)SGK1, SGK2, SGK3 or (T308D,S473D)PKB. In conclusion, all three members of the SGK family of kinases SGK1-3 and protein kinase B stimulate the slowly activating K(+) channel KCNE1/KCNQ1. The kinases may thus participate in the regulation of KCNE1-dependent transport and excitability.
Alvarez de la Rosa,
The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes.
1999, Pubmed,
Xenbase
Alvarez de la Rosa,
The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes.
1999,
Pubmed
,
Xenbase
Barhanin,
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
1996,
Pubmed
,
Xenbase
Bell,
Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway.
2000,
Pubmed
Brennan,
Rapid upregulation of serum and glucocorticoid-regulated kinase (sgk) gene expression by corticosteroids in vivo.
2000,
Pubmed
Busch,
Molecular basis of IsK protein regulation by oxidation or chelation.
1995,
Pubmed
,
Xenbase
Böhmer,
The shrinkage-activated Na(+) conductance of rat hepatocytes and its possible correlation to rENaC.
2000,
Pubmed
,
Xenbase
Chen,
Epithelial sodium channel regulated by aldosterone-induced protein sgk.
1999,
Pubmed
,
Xenbase
Debonneville,
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
2001,
Pubmed
,
Xenbase
Fillon,
Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis.
2002,
Pubmed
Gamper,
K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.
2002,
Pubmed
,
Xenbase
Gamper,
IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1.
2002,
Pubmed
Kaczmarek,
Properties and regulation of the minK potassium channel protein.
1997,
Pubmed
,
Xenbase
Kobayashi,
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
1999,
Pubmed
Kobayashi,
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
1999,
Pubmed
Lang,
Electrophysiology of sodium-coupled transport in proximal renal tubules.
1986,
Pubmed
Lang,
Potassium channels in renal epithelial transport regulation.
1992,
Pubmed
Lang,
Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms.
2001,
Pubmed
Lang,
Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.
2000,
Pubmed
,
Xenbase
Loffing,
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
2001,
Pubmed
,
Xenbase
Meier,
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
1997,
Pubmed
Neyroud,
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome.
1997,
Pubmed
Náray-Fejes-Tóth,
sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels.
1999,
Pubmed
,
Xenbase
Náray-Fejes-Tóth,
The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel.
2000,
Pubmed
,
Xenbase
Ohyama,
Inhibition of cardiac delayed rectifier K+ currents by an antisense oligodeoxynucleotide against IsK (minK) and over-expression of IsK mutant D77N in neonatal mouse hearts.
2001,
Pubmed
Pearce,
Role of SGK in mineralocorticoid-regulated sodium transport.
2000,
Pubmed
,
Xenbase
Pusch,
Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK.
1998,
Pubmed
,
Xenbase
Sable,
cAMP stimulates protein kinase B in a Wortmannin-insensitive manner.
1997,
Pubmed
Sanguinetti,
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
1996,
Pubmed
,
Xenbase
Seebohm,
Dependence of I(Ks) biophysical properties on the expression system.
2001,
Pubmed
,
Xenbase
Setiawan,
Stimulation of Xenopus oocyte Na(+),K(+)ATPase by the serum and glucocorticoid-dependent kinase sgk1.
2002,
Pubmed
,
Xenbase
Shigaev,
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel.
2000,
Pubmed
,
Xenbase
Sugimoto,
Immunohistochemical study of a rat membrane protein which induces a selective potassium permeation: its localization in the apical membrane portion of epithelial cells.
1990,
Pubmed
,
Xenbase
Takumi,
Cloning of a membrane protein that induces a slow voltage-gated potassium current.
1988,
Pubmed
,
Xenbase
Unsöld,
KCNE1 reverses the response of the human K+ channel KCNQ1 to cytosolic pH changes and alters its pharmacology and sensitivity to temperature.
2000,
Pubmed
,
Xenbase
Vallon,
Role of KCNE1-dependent K+ fluxes in mouse proximal tubule.
2001,
Pubmed
Verrey,
Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms.
2000,
Pubmed
,
Xenbase
Vetter,
Inner ear defects induced by null mutation of the isk gene.
1996,
Pubmed
Waerntges,
Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis.
2002,
Pubmed
Wagner,
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
2001,
Pubmed
,
Xenbase
Wagner,
The use of Xenopus laevis oocytes for the functional characterization of heterologously expressed membrane proteins.
2000,
Pubmed
,
Xenbase
Waldegger,
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
1997,
Pubmed
Waldegger,
h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine.
1999,
Pubmed
Waldegger,
h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells.
2000,
Pubmed
Webster,
Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.
1993,
Pubmed
Webster,
Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase.
1993,
Pubmed
Wärntges,
Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1.
2002,
Pubmed
,
Xenbase
Zinda,
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.
2001,
Pubmed
