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J Reprod Dev
2019 Jun 14;653:203-208. doi: 10.1262/jrd.2019-002.
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Various nuclear reprogramming systems using egg and oocyte materials.
Miyamoto K
.
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Maternal factors stored in eggs and oocytes are necessary for reprogramming sperm for embryonic development. This reprogramming activity of maternal factors also works towards somatic cells, including terminally differentiated cells. Several different experimental systems utilizing egg and oocyte materials have been applied to study nuclear reprogramming by maternal factors. Among these systems, the most widely used is the transfer of a somatic cell nucleus to an oocyte arrested at the metaphase II stage, leading to the production of a cloned animal. Nuclear transfer to an unfertilized oocyte thus provides a unique opportunity to examine reprogramming processes involved in acquiring totipotency. Other experimental systems are also available to study maternal reprogramming, such as nuclear transfer to Xenopus laevis oocytes at the germinal vesicle stage, treatment with extracts obtained from eggs or oocytes, and induced pluripotency with overexpressed maternal factors. Each system can be used for answering different types of scientific questions. This review describes currently available reprogramming systems using egg and oocyte materials and discusses how we can deepen our understanding of reprogramming mechanisms by taking advantage of these various experimental systems.
Fig. 1. Overview of various nuclear reprogramming systems using egg/oocyte materials. Four different reprogramming systems using egg or oocyte materials are summarized. Brief explanations of each system, including their advantages over other systems and challenges that need to be considered, are described. Please refer to relevant sections of the text for more details.
Allegrucci,
Epigenetic reprogramming of breast cancer cells with oocyte extracts.
2011, Pubmed,
Xenbase
Allegrucci,
Epigenetic reprogramming of breast cancer cells with oocyte extracts.
2011,
Pubmed
,
Xenbase
Beyhan,
Interspecies nuclear transfer: implications for embryonic stem cell biology.
2007,
Pubmed
Bian,
Epigenetic marks in somatic chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extracts.
2009,
Pubmed
Chung,
Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.
2015,
Pubmed
Djekidel,
Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent.
2018,
Pubmed
Egli,
Reprogramming within hours following nuclear transfer into mouse but not human zygotes.
2011,
Pubmed
Fatira,
Application of interspecific Somatic Cell Nuclear Transfer (iSCNT) in sturgeons and an unexpectedly produced gynogenetic sterlet with homozygous quadruple haploid.
2018,
Pubmed
GURDON,
Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei.
1958,
Pubmed
,
Xenbase
GURDON,
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles.
1962,
Pubmed
,
Xenbase
Gao,
Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos.
2018,
Pubmed
Gonzalez-Muñoz,
Cell reprogramming. Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming.
2014,
Pubmed
Haigh,
The generation of cloned Drosophila melanogaster.
2005,
Pubmed
Halley-Stott,
Mammalian nuclear transplantation to Germinal Vesicle stage Xenopus oocytes - a method for quantitative transcriptional reprogramming.
2010,
Pubmed
,
Xenbase
Hansis,
Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1.
2004,
Pubmed
,
Xenbase
Hiiragi,
Reprogramming is essential in nuclear transfer.
2005,
Pubmed
Hill,
Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses.
2000,
Pubmed
Hörmanseder,
H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos.
2017,
Pubmed
,
Xenbase
Inoue,
Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.
2010,
Pubmed
Jullien,
Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation.
2010,
Pubmed
,
Xenbase
Jullien,
Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
2011,
Pubmed
,
Xenbase
Jullien,
HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes.
2012,
Pubmed
,
Xenbase
Jullien,
Hierarchical molecular events driven by oocyte-specific factors lead to rapid and extensive reprogramming.
2014,
Pubmed
,
Xenbase
Jullien,
Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways.
2017,
Pubmed
,
Xenbase
Kang,
Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos.
2014,
Pubmed
Khaw,
Oocyte Factors Suppress Mitochondrial Polynucleotide Phosphorylase to Remodel the Metabolome and Enhance Reprogramming.
2015,
Pubmed
Kikyo,
Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI.
2000,
Pubmed
,
Xenbase
Kim,
Epigenetic memory in induced pluripotent stem cells.
2010,
Pubmed
Koziol,
Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei.
2007,
Pubmed
,
Xenbase
Kunitomi,
H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
2016,
Pubmed
Lemaitre,
Mitotic remodeling of the replicon and chromosome structure.
2005,
Pubmed
,
Xenbase
Lin,
Defects in trophoblast cell lineage account for the impaired in vivo development of cloned embryos generated by somatic nuclear transfer.
2011,
Pubmed
Liu,
Increased blastocyst formation of cloned porcine embryos produced with donor cells pre-treated with Xenopus egg extract and/or digitonin.
2012,
Pubmed
,
Xenbase
Liu,
Cell colony formation induced by Xenopus egg extract as a marker for improvement of cloned blastocyst formation in the pig.
2011,
Pubmed
,
Xenbase
Liu,
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.
2016,
Pubmed
Liu,
Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.
2018,
Pubmed
Liu,
H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.
2018,
Pubmed
Liu,
Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by single-embryo RNA sequencing.
2018,
Pubmed
Ma,
Abnormalities in human pluripotent cells due to reprogramming mechanisms.
2014,
Pubmed
Maekawa,
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
2011,
Pubmed
Mandai,
Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.
2017,
Pubmed
Matoba,
RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos.
2011,
Pubmed
Matoba,
Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation.
2014,
Pubmed
Matoba,
Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development.
2018,
Pubmed
Misu,
Nuclear Actin in Development and Transcriptional Reprogramming.
2017,
Pubmed
Miyamoto,
Reprogramming events of mammalian somatic cells induced by Xenopus laevis egg extracts.
2007,
Pubmed
,
Xenbase
Miyamoto,
Reversible membrane permeabilization of mammalian cells treated with digitonin and its use for inducing nuclear reprogramming by Xenopus egg extracts.
2008,
Pubmed
,
Xenbase
Miyamoto,
Cell-free extracts from mammalian oocytes partially induce nuclear reprogramming in somatic cells.
2009,
Pubmed
Miyamoto,
Identification and characterization of an oocyte factor required for development of porcine nuclear transfer embryos.
2011,
Pubmed
Miyamoto,
Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes.
2011,
Pubmed
,
Xenbase
Miyamoto,
Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development.
2013,
Pubmed
,
Xenbase
Miyamoto,
Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules.
2017,
Pubmed
Miyamoto,
Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes.
2018,
Pubmed
,
Xenbase
Narbonne,
Reprogramming and development in nuclear transfer embryos and in interspecific systems.
2012,
Pubmed
Normile,
iPS cell therapy reported safe.
2017,
Pubmed
Parisis,
Initiation of DNA replication requires actin dynamics and formin activity.
2017,
Pubmed
,
Xenbase
Pasque,
Histone variant macroH2A confers resistance to nuclear reprogramming.
2011,
Pubmed
,
Xenbase
Rathbone,
Reprogramming of ovine somatic cells with Xenopus laevis oocyte extract prior to SCNT improves live birth rate.
2010,
Pubmed
,
Xenbase
Ruan,
XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer.
2018,
Pubmed
Shinagawa,
Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
2014,
Pubmed
Siripattarapravat,
Somatic cell nuclear transfer in zebrafish.
2009,
Pubmed
Takahashi,
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
2006,
Pubmed
Takahashi,
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
2007,
Pubmed
Wakayama,
Cloning of male mice from adult tail-tip cells.
1999,
Pubmed
Wakayama,
Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei.
1998,
Pubmed
Wilmut,
Viable offspring derived from fetal and adult mammalian cells.
1997,
Pubmed
Wu,
Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation.
2017,
Pubmed
Yang,
Xenopus egg extract treatment reduced global DNA methylation of donor cells and enhanced somatic cell nuclear transfer embryo development in pigs.
2012,
Pubmed
,
Xenbase
Yu,
Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning.
2018,
Pubmed
