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Hypoxia (Auckl) 2018 Jan 12;6:1-9. doi: 10.2147/HP.S151536.
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A multichannel computer-driven system to raise aquatic embryos under selectable hypoxic conditions.

Metikala S , Neuhaus H , Hollemann T .

The formation of a functional cardiovascular system is an essential step in the early vertebrate embryo. Nevertheless, the effect of hypoxia on the developmental program of organisms was studied rarely. In particular, this holds true for vertebrate embryos that depend on a functional placenta for proper development and had not been studied in this respect due to the obvious limitation. We established a protocol to culture aquatic embryos, which enabled us to culture a high number of Xenopus embryos until tadpole stage under defined hypoxic conditions in four hypoxia chambers simultaneously, employing a computerized system. In general, our results show that hypoxia results in delayed development and, in particular, we could show that oxygen availability was most crucial during gastrulation and organogenesis (early tailbud) phases during embryonic development of Xenopus laevis.

PubMed ID: 29392150
PMC ID: PMC5769780
Article link: Hypoxia (Auckl)

Genes referenced: cfd etv2 gnas rpe

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References [+] :
Cao, Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy. 2008, Pubmed