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Dev Growth Differ 2017 Aug 01;596:526-539. doi: 10.1111/dgd.12382.
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Comprehensive analyses of hox gene expression in Xenopus laevis embryos and adult tissues.

Kondo M , Yamamoto T , Takahashi S , Taira M .

From whole genome sequencing of an allotetraploid frog, Xenopus laevis, two homeologous sets (L and S) of four Hox clusters A through D (HoxA.L/S, HoxB.L/S, HoxC.L/S, and HoxD.L/S) and 13 paralogous groups (PGs) with 76 genes were identified, allowing us to carry out the first comprehensive analyses of hox gene expression in vertebrates. Expression of all hox genes during development and in adult tissues was analyzed by RNA-sequencing. The expression levels of most hox genes were similar between homeologs, but in some pairs, large differences were observed and several of these were confirmed by RT-PCR and whole mount in situ hybridization experiments. These results indicate that subfunctionalization of hox genes may have occurred since allotetraploidization. Furthermore, comprehensive analysis of hox gene expression during early development did not agree with the hypothesis of temporal collinearity especially in genes belonging to PG2 to PG10.

PubMed ID: 28791673
Article link: Dev Growth Differ

Species referenced: Xenopus laevis
Genes referenced: hoxa1 hoxa10 hoxa11 hoxa13 hoxa2 hoxa3 hoxa4 hoxa5 hoxa6 hoxa7 hoxa9 hoxb1 hoxb2 hoxb3 hoxb4 hoxb5 hoxb6 hoxb7 hoxb8 hoxb9 hoxc10 hoxc11 hoxc12 hoxc13 hoxc3 hoxc4 hoxc5 hoxc6 hoxc8 hoxc9 hoxd1 hoxd10 hoxd11 hoxd13 hoxd3 hoxd4 hoxd8 hoxd9 odc1

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