XB-ART-53324
Semin Cell Dev Biol
2015 Jun 01;42:118-33. doi: 10.1016/j.semcdb.2015.06.003.
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Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes.
Tuazon FB
,
Mullins MC
.
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The vertebrate body plan is established through the precise spatiotemporal coordination of morphogen signaling pathways that pattern the anteroposterior (AP) and dorsoventral (DV) axes. Patterning along the AP axis is directed by posteriorizing signals Wnt, fibroblast growth factor (FGF), Nodal, and retinoic acid (RA), while patterning along the DV axis is directed by bone morphogenetic proteins (BMP) ventralizing signals. This review addresses the current understanding of how Wnt, FGF, RA and BMP pattern distinct AP and DV cell fates during early development and how their signaling mechanisms are coordinated to concomitantly pattern AP and DV tissues.
???displayArticle.pubmedLink??? 26123688
???displayArticle.pmcLink??? PMC4562868
???displayArticle.link??? Semin Cell Dev Biol
???displayArticle.grants??? [+]
R01 GM056326 NIGMS NIH HHS , T32 GM007229 NIGMS NIH HHS , F31-GM113362-01 NIGMS NIH HHS , T32-GM007229 NIGMS NIH HHS , F31 GM113362 NIGMS NIH HHS , R01-GM56326-16 NIGMS NIH HHS
Species referenced: Xenopus
Genes referenced: bmp4 chrd cyp26a1 egr2 fst gsc hoxb1 lefty nodal nodal1 pax2 six3 spry1 szl ventx1 wnt1
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