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Nat Commun 2015 Aug 05;6:7889. doi: 10.1038/ncomms8889.
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An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.

Meunier S , Shvedunova M , Van Nguyen N , Avila L , Vernos I , Akhtar A .

The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

PubMed ID: 26243146
PMC ID: PMC4918316
Article link: Nat Commun

Species referenced: Xenopus laevis
Genes referenced: h2bc21 kansl1 kansl3 kat8 kif2c mbp mcrs1 ndc80 tpx2

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References [+] :
Cai, Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. 2010, Pubmed