Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Cell Rep 2015 May 19;117:1000-7. doi: 10.1016/j.celrep.2015.04.025.
Show Gene links Show Anatomy links

TGF-β Signaling Regulates the Differentiation of Motile Cilia.

Tözser J , Earwood R , Kato A , Brown J , Tanaka K , Didier R , Megraw TL , Blum M , Kato Y .

The cilium is a small cellular organelle with motility- and/or sensory-related functions that plays a crucial role during developmental and homeostatic processes. Although many molecules or signal transduction pathways that control cilia assembly have been reported, the mechanisms of ciliary length control have remained enigmatic. Here, we report that Smad2-dependent transforming growth factor β (TGF-β) signaling impacts the length of motile cilia at the Xenopus left-right (LR) organizer, the gastrocoel roof plate (GRP), as well as at the neural tube and the epidermis. Blocking TGF-β signaling resulted in the absence of the transition zone protein B9D1/MSKR-1 from cilia in multi-ciliated cells (MCCs) of the epidermis. Interestingly, this TGF-β activity is not mediated by Mcidas, Foxj1, and RFX2, the known major regulators of ciliogenesis. These data indicate that TGF-β signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

PubMed ID: 25959824
PMC ID: PMC4439334
Article link: Cell Rep
Grant support: [+]

Species referenced: Xenopus
Genes referenced: acvr1b acvr2b b9d1 dll1 foxj1 foxj1.2 gdf3 jag1 mcc mcidas nodal1 notch1 odad4 rfx2 rho rpsa smad2 tbx2 tuba4b tubg1
Morpholinos: gdf3 MO1 nodal1 MO5 notch1 MO1

Article Images: [+] show captions
References [+] :
Antic, Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. 2010, Pubmed, Xenbase