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J Cell Biochem 2014 Aug 01;1158:1343-50. doi: 10.1002/jcb.24810.
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Gene regulatory networks governing lung specification.

The epithelial lining of the respiratory system originates from a small group of progenitor cells in the ventral foregut endoderm of the early embryo. Research in the last decade has revealed a number of paracrine signaling pathways that are critical for the development of these respiratory progenitors. In the post-genomic era the challenge now is to figure out at the genome wide level how these different signaling pathways and their downstream transcription factors interact in a complex "gene regulatory network" (GRN) to orchestrate early lung development. In this prospective, we review our growing understanding of the GRN governing lung specification. We discuss key gaps in our knowledge and describe emerging opportunities that will soon provide an unprecedented understanding of lung development and accelerate our ability to apply this knowledge to regenerative medicine.

PubMed ID: 24644080
PMC ID: PMC4263286
Article link: J Cell Biochem
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bmp4 bmp7.1 bmp7.2 cdx2 dkk1 fgf10 fgfr2 foxa2 gata6 gli2 gli3 grn hoxa5 nkx2-1 osr1 osr2 shh smad1 sox2 tbx5 wnt2 wnt2b

References [+] :
Arda, Gene regulatory networks governing pancreas development. 2013, Pubmed