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Nat Commun 2015 Jan 19;6:6017. doi: 10.1038/ncomms7017.
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mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes.

Takahashi C , Kusakabe M , Suzuki T , Miyatake K , Nishida E .

Cell fate specifications of multiciliate cells (MCCs) and ionocytes are commonly suppressed by the Notch pathway in developing epithelia, but are governed by different master regulators, suggesting the existence of a common regulator linking the Notch pathway to both MCC and ionocyte specifications. Here we show that a mab21 family gene, mab21-l3, represents the missing link. In Xenopus embryonic epidermis, mab21-l3 expression is specifically found in MCCs and ionocytes and is downregulated by the Notch pathway. Knockdown of mab21-l3 in Xenopus downregulates both MCC-specific and ionocyte-specific master genes, resulting in drastic loss of MCCs and ionocytes. In mouse tracheal epithelial cells, mab21-l3 expression is also downregulated by the Notch pathway and is required for MCC differentiation. Moreover, conditional gain of function of mab21-l3 rescues Notch-induced loss of MCCs and ionocytes in Xenopus. These results indicate that mab21-l3 acts downstream of the Notch pathway in cell fate specifications of MCCs and ionocytes.

PubMed ID: 25598413
Article link: Nat Commun

Species referenced: Xenopus laevis
Genes referenced: mab21l3 mcc notch1 slc26a4.3 slc4a1

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