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XB-ART-49533
Cilia 2013 Oct 07;2:13.
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The Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteins.



Abstract
Cilia are small, microtubule-based protrusions important for development and homeostasis. We recently demonstrated that the planar cell polarity effector protein Fuz is a critical regulator of axonemal intraflagellar transport dynamics and localization. Here, we report our findings on the role of the small GTPase Rsg1, a known binding partner of Fuz, and its role in the dynamics and cytoplasmic localization of intraflagellar transport proteins. We find that Rsg1 loss of function leads to impaired axonemal IFT dynamics in multiciliated cells. We further show that Rsg1 is required for appropriate cytoplasmic localization of the retrograde IFT-A protein IFT43. Finally, we show that Rsg1 governs the apical localization of basal bodies, the anchoring structures of cilia. Our data suggest that Rsg1 is a regulator of multiple aspects of ciliogenesis, including apical trafficking of basal bodies and the localization and dynamics intraflagellar transport proteins.

PubMed ID: 24192041
PMC ID: PMC3850895



Species referenced: Xenopus
Genes referenced: cplane2 fuz grap2 ift20 ift43 map7 mcc plin1
Morpholinos: cplane2l MO1


Article Images: [+] show captions
References [+] :
Arts, C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome. 2011, Pubmed